iPTMnet Report for Q9UKK3 (PARP4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UKK3 / PARP4_HUMAN
Protein Name Protein mono-ADP-ribosyltransferase PARP4
Gene Name Name: PARP4
Synonyms:ADPRTL1;
Organism Homo sapiens (Human)

PRO ID PR:Q9UKK3
DAG View
PRO Name protein mono-ADP-ribosyltransferase PARP4 (human)
Definition A protein mono-ADP-ribosyltransferase PARP4 that is encoded in the genome of human.
Short Label hPARP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UKK3 (PARP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K16 Ubiquitination PhosphoSitePlus
Y17 Phosphorylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
T28 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
Y95 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
T101 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
K107 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
Y214 Phosphorylation PhosphoSitePlus
Y218 Phosphorylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus   UniProt 23186163
K336 Ubiquitination PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
T362 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
C503 Methylation IEDB 31844290
K572 Ubiquitination PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
K664 Ubiquitination PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
T768 Phosphorylation PhosphoSitePlus
K771 Ubiquitination PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
S830 Phosphorylation PhosphoSitePlus
S836 Phosphorylation PhosphoSitePlus
S904 Phosphorylation PhosphoSitePlus
Y959 Phosphorylation PhosphoSitePlus
C1019 Methylation IEDB 31844290
K1030 Ubiquitination PhosphoSitePlus
K1037 Ubiquitination PhosphoSitePlus
S1048 Phosphorylation PhosphoSitePlus
T1109 Phosphorylation PhosphoSitePlus
S1112 Phosphorylation PhosphoSitePlus
T1120 Phosphorylation HPRD 20068231
T1122 Phosphorylation PhosphoSitePlus
K1126 Ubiquitination PhosphoSitePlus
K1151 Ubiquitination PhosphoSitePlus
T1173 Phosphorylation PhosphoSitePlus
S1174 Phosphorylation PhosphoSitePlus
S1186 Phosphorylation PhosphoSitePlus
K1193 Ubiquitination PhosphoSitePlus
K1200 Ubiquitination PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
S1227 Phosphorylation PhosphoSitePlus
S1228 Phosphorylation PhosphoSitePlus
S1236 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S1253 Phosphorylation PhosphoSitePlus
S1274 Phosphorylation IEDB 32387766
S1288 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1292 Phosphorylation PhosphoSitePlus
K1294 Ubiquitination PhosphoSitePlus
K1303 Ubiquitination PhosphoSitePlus
K1304 Ubiquitination PhosphoSitePlus
S1306 Phosphorylation PhosphoSitePlus
T1312 O-Glycosylation GlyGen 34725712, 30059200, 35254053, ...35132862, 31492838, 29351928, 28657654
S1314 O-Glycosylation GlyGen 34725712, 30059200, 35254053, ...35132862, 31492838, 29351928, 28657654
R1332 Methylation PhosphoSitePlus
S1335 O-Glycosylation GlyGen 34725712, 30059200, 35254053, ...35132862, 31492838, 29351928, 28657654
S1335 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18669648, ...18707149, 20068231
S1338 O-Glycosylation GlyGen 34725712, 30059200, 35254053, ...35132862, 31492838, 29351928, 28657654, 29237092
S1338 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S1340 Phosphorylation PhosphoSitePlus
S1343 Phosphorylation PhosphoSitePlus
R1345 Methylation PhosphoSitePlus
S1349 Phosphorylation PhosphoSitePlus
S1434 Phosphorylation PhosphoSitePlus
R1449 Methylation PhosphoSitePlus
R1476 Methylation PhosphoSitePlus   UniProt 24129315
T1493 Phosphorylation PhosphoSitePlus
T1494 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1504 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1507 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1535 Phosphorylation PhosphoSitePlus
S1548 Phosphorylation PhosphoSitePlus
T1600 Phosphorylation PhosphoSitePlus
S1605 Phosphorylation PhosphoSitePlus
S1614 Phosphorylation PhosphoSitePlus
T1629 Phosphorylation PhosphoSitePlus
K1648 Ubiquitination PhosphoSitePlus
S1649 Phosphorylation PhosphoSitePlus
S1710 Phosphorylation PhosphoSitePlus
S1713 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y1721 Phosphorylation PhosphoSitePlus
S1722 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K16 E16 Biomuta DOID:363 / uterine cancer [ icgc ]
K23 E23 Biomuta DOID:4159 / skin cancer [ cosmic ]
S63 Y63 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K79 R79 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K90 N90 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K96 M96 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K223 N223 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K397 I397 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K429 E429 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K594 N594 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K629 R629 Biomuta DOID:1324 / lung cancer [ cosmic ]
K629 E629 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K677 R677 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S904 F904 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1109 S1109 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1112 * Biomuta DOID:184 / bone cancer [ cosmic ]
S1236 F1236 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1294 N1294 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T1312 I1312 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
R1332 H1332 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1335 N1335 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R1345 C1345 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S1434 F1434 Biomuta DOID:9256 / colorectal cancer [ cosmic ]