Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UKG1 / DP13A_HUMAN
Protein Name DCC-interacting protein 13-alpha
Gene Name Name: APPL1
Synonyms:APPL;
Organism Homo sapiens (Human)

PRO ID PR:Q9UKG1
DAG View
PRO Name DCC-interacting protein 13-alpha (human)
Definition A DCC-interacting protein 13-alpha that is encoded in the genome of human.
Short Label hAPPL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UKG1 (APPL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K350 Acetylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
Y378 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
T399 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S401 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 15302935, 19664994, ...19664995, 17322306, 18669648, 21562756, 20068231
S403 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S410 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 29212031, 17765681
S410 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 17765681
T422 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
S428 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus 22685300
S430 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 22685300
S459 Phosphorylation PhosphoSitePlus
T479 Phosphorylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
Y522 Phosphorylation PhosphoSitePlus
T524 Phosphorylation PhosphoSitePlus
Y604 Phosphorylation PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
K661 Ubiquitination PhosphoSitePlus
S689 Phosphorylation PhosphoSitePlus
S691 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
S693 Phosphorylation PhosphoSitePlus
S696 Phosphorylation PhosphoSitePlus
S707 Phosphorylation RLIMS-P 27300007


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S258 N258 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K350 E350 Biomuta DOID:4362 / cervical cancer [ tcga ]
K351 Q351 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T399 A399 Biomuta DOID:1909 / melanoma [ cosmic ]
S427 T427 Biomuta DOID:363 / uterine cancer [ tcga ]
S459 Y459 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ]
K490 T490 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
S693 L693 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]