iPTMnet Report for Q9UKF6 (CPSF3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UKF6 / CPSF3_HUMAN
Protein Name Cleavage and polyadenylation specificity factor subunit 3
Gene Name Name: CPSF3
Synonyms:CPSF73;
Organism Homo sapiens (Human)

PRO ID PR:Q9UKF6
DAG View
PRO Name cleavage and polyadenylation specificity factor subunit 3 (human)
Definition A cleavage and polyadenylation specificity factor subunit 3 that is encoded in the genome of human.
Short Label hCPSF3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UKF6 (CPSF3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22223895
C27 Methylation IEDB 31844290
K33 Ubiquitination PhosphoSitePlus
T126 Phosphorylation PhosphoSitePlus
C153 Methylation IEDB 31844290
R232 Methylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K462 Sumoylation PhosphoSitePlus
K465 Sumoylation PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
Y492 Phosphorylation PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
Y503 Phosphorylation PhosphoSitePlus
T504 Phosphorylation PhosphoSitePlus
K545 Sumoylation PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
K549 Ubiquitination PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
K612 Ubiquitination PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus
C655 S-Nitrosylation dbSNO 26338901
S659 Phosphorylation PhosphoSitePlus
Y677 Phosphorylation PhosphoSitePlus
T681 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19664994, 23186163, 19664995, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S328 Y328 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K410 T410 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K612 N612 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S633 Y633 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T681 M681 Biomuta [ cosmic ]