Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UKE5 / TNIK_HUMAN
Protein Name TRAF2 and NCK-interacting protein kinase
Gene Name Name: TNIK
Synonyms:KIAA0551;
Organism Homo sapiens (Human)

PRO ID PR:Q9UKE5
DAG View
PRO Name TRAF2 and NCK-interacting protein kinase (human)
Definition A TRAF2 and NCK-interacting protein kinase that is encoded in the genome of human.
Short Label hTNIK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UKE5 (TNIK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
Y36 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
Y86 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
Y323 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus   UniProt 21406692
S335 Phosphorylation PhosphoSitePlus
Y427 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
Y475 Phosphorylation PhosphoSitePlus
Y499 Phosphorylation PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
Y519 Phosphorylation PhosphoSitePlus
Y521 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus   UniProt 19369195
S568 Phosphorylation PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus   UniProt 23186163
S574 Phosphorylation PhosphoSitePlus
T581 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087
S600 Phosphorylation PhosphoSitePlus   UniProt 23186163
S608 Phosphorylation PhosphoSitePlus   UniProt 23186163
S610 Phosphorylation PhosphoSitePlus   UniProt 23186163
S640 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18088087, 19369195, ...24275569, 23186163
T643 Phosphorylation PhosphoSitePlus
S660 Phosphorylation PhosphoSitePlus
T677 Phosphorylation PhosphoSitePlus
S678 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 18669648, 23186163
S680 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17192257, 18669648, ...24275569, 18088087
S688 Phosphorylation PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...19369195
R698 Methylation PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus   UniProt 23186163
R705 Methylation PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
S720 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
S726 Phosphorylation PhosphoSitePlus
S729 Phosphorylation PhosphoSitePlus
S755 Phosphorylation PhosphoSitePlus
S764 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18088087, 15144186, 30901730, ...17192257, 23186163
S766 Phosphorylation PhosphoSitePlus   UniProt 19369195
S769 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 18088087, ...19369195, 15144186, 17192257, 23186163
S795 Phosphorylation PhosphoSitePlus
K824 Acetylation PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus
T902 Phosphorylation PhosphoSitePlus
S936 Phosphorylation PhosphoSitePlus
S938 Phosphorylation PhosphoSitePlus
T942 Phosphorylation PhosphoSitePlus
S954 Phosphorylation PhosphoSitePlus
S959 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y963 Phosphorylation PhosphoSitePlus
S972 Phosphorylation PhosphoSitePlus
Y982 Phosphorylation PhosphoSitePlus
T987 Phosphorylation PhosphoSitePlus
S1021 Phosphorylation PhosphoSitePlus
T1036 Phosphorylation PhosphoSitePlus
S1116 Phosphorylation PhosphoSitePlus
K1131 Ubiquitination PhosphoSitePlus
K1178 Ubiquitination PhosphoSitePlus
Y1264 Phosphorylation PhosphoSitePlus
T1267 Phosphorylation PhosphoSitePlus
K1319 Ubiquitination PhosphoSitePlus
K1325 Ubiquitination PhosphoSitePlus
K1333 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T181 Phosphorylation Q9UKE5 (TNIK) HPRD 17192257
T319 Phosphorylation HPRD 18691976
Y321 Phosphorylation HPRD 18691976
Y323 Phosphorylation HPRD 18452278
S324 Phosphorylation HPRD 18691976, 18452278
S326 Phosphorylation HPRD 18691976, 18452278
S348 Phosphorylation HPRD 18452278
S547 Phosphorylation HPRD 18691976
S560 Phosphorylation HPRD 18691976
T581 Phosphorylation HPRD 19651622, 18088087
S640 Phosphorylation Q9UKE5 (TNIK) HPRD 19651622, 18691976, 18088087, ...19664995, 17192257
T677 Phosphorylation HPRD 18088087
S678 Phosphorylation HPRD 19413330, 18691976, 18669648, ...19664995, 19651622
S680 Phosphorylation Q9UKE5 (TNIK) HPRD 19413330, 18691976, 18088087, ...19664994, 19664995, 17192257, 19651622, 18669648
S688 Phosphorylation HPRD 19651622, 18691976
S701 Phosphorylation HPRD 19651622, 18691976
S707 Phosphorylation HPRD 18691976
S720 Phosphorylation HPRD 18691976
S726 Phosphorylation HPRD 19413330
S755 Phosphorylation HPRD 19413330
S764 Phosphorylation HPRD 18691976, 18088087, 15144186
S766 Phosphorylation HPRD 19651622, 18691976
S769 Phosphorylation HPRD 18691976, 18088087, 20058876, ...15144186, 19651622, 20166139
S915 Phosphorylation HPRD 18691976
S985 Phosphorylation HPRD 18691976
S1034 Phosphorylation HPRD 18691976
T1036 Phosphorylation HPRD 18691976


Q9UKE5 (TNIK) as PTM Enzyme



Substrate Site Score Source PMID
Q15797 (SMAD1) T322 neXtProt 21690388
Q9NQB0 (TCF7L2) S177 neXtProt   PhosphoSitePlus   Signor 20530691
Q9UKE5-1 (TNIK) T181 HPRD 17192257
Q9UKE5-1 (TNIK) S640 HPRD 19651622, 18691976, 18088087, ...19664995, 17192257
Q9UKE5-1 (TNIK) S680 HPRD 19413330, 18691976, 18088087, ...19664994, 19664995, 17192257, 19651622, 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K46 E46 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K303 M303 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T319 K319 Biomuta DOID:3571 / liver cancer [ icgc ]
Y321 * Biomuta DOID:2394 / ovarian cancer [ tcga ]
S348 L348 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S526 R526 Biomuta DOID:363 / uterine cancer [ tcga ]
S560 C560 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S568 L568 Biomuta DOID:1909 / melanoma [ cosmic ]
S600 F600 Biomuta DOID:1909 / melanoma [ tcga ]
S678 F678 Biomuta DOID:363 / uterine cancer [ tcga ]
S688 Y688 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S726 T726 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S726 R726 Biomuta DOID:3571 / liver cancer [ icgc ]
S795 R795 Biomuta DOID:3571 / liver cancer [ icgc ]
S936 G936 Biomuta DOID:2596 / larynx cancer [ cosmic ]
S985 F985 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1021 L1021 Biomuta DOID:4362 / cervical cancer [ icgc, tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ tcga ] DOID:3070 / malignant glioma [ tcga ]
S1021 T1021 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K1131 N1131 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K1131 R1131 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K1319 T1319 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K1325 T1325 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]