iPTMnet Report for Q9UKC9 (FBXL2)
Protein Information
| UniProt AC / UniProt ID | Q9UKC9 / FBXL2_HUMAN |
| Protein Name | F-box/LRR-repeat protein 2 |
| Gene Name | Name: FBXL2 Synonyms:FBL2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9UKC9 |
| PRO Name | F-box/LRR-repeat protein 2 (human) |
| Definition | An F-box/LRR-repeat protein 2 that is encoded in the genome of human. |
| Short Label | hFBXL2 |
| Category | organism-gene |
DAG ViewQ9UKC9 (FBXL2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S4 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K13 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K74 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K201 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T404 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P | 27010866, 23542741 |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | O00459 (PIK3R2) | Y655 | Q9UKC9 (FBXL2) | inhibited_association | eFIP | 23604317 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K13 | E13 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| K74 | R74 | Biomuta | [ cosmic ] |
