iPTMnet Report for Q9UKA4 (AKAP11)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UKA4 / AKA11_HUMAN
Protein Name A-kinase anchor protein 11
Gene Name Name: AKAP11
Synonyms:AKAP220,KIAA0629;
Organism Homo sapiens (Human)

PRO ID PR:Q9UKA4
DAG View
PRO Name A-kinase anchor protein 11 (human)
Definition An A-kinase anchor protein 11 that is encoded in the genome of human.
Short Label hAKAP11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UKA4 (AKAP11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 19690332
S20 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
T150 Phosphorylation PhosphoSitePlus
T199 Phosphorylation HPRD 17081983
S200 Phosphorylation HPRD 17081983
N208 N-Glycosylation GlyGen 29741879
S239 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
T250 Phosphorylation PhosphoSitePlus
S271 O-Glycosylation GlyGen 30620550
S273 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
S422 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y424 Phosphorylation PhosphoSitePlus
S433 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
K438 Methylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus   UniProt 23186163
S448 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 23186163, 18691976, ...19664994, 18669648
S456 Phosphorylation PhosphoSitePlus
Y485 Phosphorylation PhosphoSitePlus
Y486 Phosphorylation HPRD   PhosphoSitePlus 15592455
Y488 Phosphorylation HPRD   PhosphoSitePlus 15592455
Y491 Phosphorylation HPRD   PhosphoSitePlus 15592455
S502 Phosphorylation PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K529 Methylation PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus
S561 O-Glycosylation GlyGen 23301498, 28657654, 29351928
S606 Phosphorylation PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
T713 O-Glycosylation GlyGen 23301498, 28657654, 29351928
T714 O-Glycosylation GlyGen 23301498, 28657654, 29351928
S719 O-Glycosylation GlyGen 23301498, 28657654, 29351928
S721 O-Glycosylation GlyGen 23301498, 28657654, 29351928
T722 O-Glycosylation GlyGen 23301498, 28657654, 29351928
S732 O-Glycosylation GlyGen 23301498, 28657654, 29351928
S736 O-Glycosylation GlyGen 23301498, 28657654, 29351928
T737 O-Glycosylation GlyGen 23301498, 28657654, 29351928
T741 O-Glycosylation GlyGen 23301498, 28657654, 29351928
S743 O-Glycosylation GlyGen 23301498, 28657654, 29351928
S745 O-Glycosylation GlyGen 23301498, 28657654, 29351928
S812 Phosphorylation PhosphoSitePlus
T853 O-Glycosylation GlyGen 23301498, 28657654, 29351928
K909 Ubiquitination PhosphoSitePlus
S919 Phosphorylation PhosphoSitePlus
S945 Phosphorylation PhosphoSitePlus
K963 Ubiquitination PhosphoSitePlus
T981 Phosphorylation PhosphoSitePlus   UniProt 23186163
S985 Phosphorylation PhosphoSitePlus
S1013 Phosphorylation PhosphoSitePlus
S1018 Phosphorylation PhosphoSitePlus
S1019 Phosphorylation PhosphoSitePlus
S1059 O-Glycosylation GlyGen 23301498, 28657654, 29351928
T1100 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 19369195, ...19651622, 18669648, 19690332
S1103 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T1104 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1109 Phosphorylation PhosphoSitePlus
S1113 Phosphorylation PhosphoSitePlus
T1136 O-Glycosylation GlyGen 23301498, 28657654, 29351928
T1136 Phosphorylation PhosphoSitePlus   Signor 26088133
T1136 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 26088133
T1140 Phosphorylation PhosphoSitePlus 26088133
T1140 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 26088133
S1144 O-Glycosylation GlyGen 23301498, 28657654, 29351928
S1169 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18691976
S1171 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1176 Phosphorylation PhosphoSitePlus
T1204 Phosphorylation PhosphoSitePlus
S1240 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18691976, 18669648
S1242 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...19664995, 18669648, 19690332
T1244 Phosphorylation PhosphoSitePlus
T1255 O-Glycosylation GlyGen 23301498, 28657654, 29351928
K1287 Acetylation PhosphoSitePlus
S1289 Phosphorylation PhosphoSitePlus
Y1291 Phosphorylation PhosphoSitePlus
Y1298 Phosphorylation PhosphoSitePlus
K1299 Acetylation PhosphoSitePlus
S1337 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1340 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T1342 Phosphorylation PhosphoSitePlus
S1360 Phosphorylation PhosphoSitePlus
Y1367 Phosphorylation PhosphoSitePlus
K1377 Ubiquitination PhosphoSitePlus
T1386 Phosphorylation IEDB 32387766
K1388 Ubiquitination PhosphoSitePlus
Y1455 Phosphorylation PhosphoSitePlus
K1470 Ubiquitination PhosphoSitePlus
S1476 Phosphorylation PhosphoSitePlus
T1485 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1487 Phosphorylation PhosphoSitePlus
K1492 Ubiquitination PhosphoSitePlus
S1493 Phosphorylation PhosphoSitePlus
T1504 Phosphorylation PhosphoSitePlus
S1523 Phosphorylation PhosphoSitePlus
T1524 O-Glycosylation GlyGen 23301498, 28657654, 29351928
T1524 Phosphorylation PhosphoSitePlus
S1526 O-Glycosylation GlyGen 23301498, 28657654, 29351928
S1526 Phosphorylation PhosphoSitePlus
Y1530 Phosphorylation PhosphoSitePlus
S1569 Phosphorylation IEDB   PhosphoSitePlus 32387766
K1578 Ubiquitination PhosphoSitePlus
S1580 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1583 Phosphorylation PhosphoSitePlus
S1611 Phosphorylation IEDB   PhosphoSitePlus 35494241
K1616 Ubiquitination PhosphoSitePlus
S1619 Phosphorylation PhosphoSitePlus
S1636 Phosphorylation PhosphoSitePlus
S1737 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S448 I448 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y485 C485 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S561 R561 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K608 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S613 I613 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S613 N613 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S613 G613 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S721 C721 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S736 L736 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S743 F743 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S919 F919 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S945 C945 Biomuta DOID:1612 / breast cancer [ cosmic ]
S985 P985 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1013 F1013 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1059 P1059 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1059 Y1059 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1144 L1144 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1144 P1144 Biomuta DOID:363 / uterine cancer [ icgc ]
S1176 N1176 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1242 L1242 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1289 R1289 Biomuta DOID:363 / uterine cancer [ icgc ]
T1342 I1342 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1360 N1360 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
K1377 T1377 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y1455 H1455 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1476 C1476 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1523 T1523 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1524 I1524 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K1616 M1616 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S1619 C1619 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1636 I1636 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1636 T1636 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1737 F1737 Biomuta DOID:4159 / skin cancer [ cosmic ]