iPTMnet Report for Q9UK80 (USP21)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UK80 / UBP21_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 21
Gene Name Name: USP21
Synonyms:USP23;ORFNames:PP1490;
Organism Homo sapiens (Human)

PRO ID PR:Q9UK80
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 21 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 21 that is encoded in the genome of human.
Short Label hUSP21
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UK80 (USP21) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S93 Phosphorylation PhosphoSitePlus   RLIMS-P 28254948
T106 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
Y290 Phosphorylation IEDB   PhosphoSitePlus 35494241
Y297 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus   RLIMS-P 28254948
K407 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus   RLIMS-P 28254948
Site PTM Type PTM Enzyme Score Source PMID
S116 Phosphorylation HPRD 19413330
T132 Phosphorylation HPRD 19413330
S140 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S116 N116 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y297 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S538 F538 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]