iPTMnet Report for Q9UK59 (DBR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UK59 / DBR1_HUMAN
Protein Name Lariat debranching enzyme
Gene Name Name: DBR1
Organism Homo sapiens (Human)

PRO ID PR:Q9UK59
DAG View
PRO Name lariat debranching enzyme (human)
Definition A lariat debranching enzyme that is encoded in the genome of human.
Short Label hDBR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UK59 (DBR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S69 Phosphorylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus   UniProt 19608861
K186 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
T245 O-Glycosylation GlyGen 23301498, 30379171, 28510447
K250 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
Y396 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus   UniProt 24275569
S474 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S478 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S479 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S485 Phosphorylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
S514 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
Y533 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S474 Phosphorylation HPRD 18691976, 18669648
S478 Phosphorylation HPRD 18691976, 18669648, 20068231
S479 Phosphorylation HPRD 18691976, 18669648, 20068231
S514 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K330 N330 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K330 Q330 Biomuta DOID:363 / uterine cancer [ icgc ]
S474 C474 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S478 Y478 Biomuta DOID:9256 / colorectal cancer [ cosmic ]