Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UK58 / CCNL1_HUMAN
Protein Name Cyclin-L1
Gene Name Name: CCNL1
ORFNames:BM-001,UNQ530/PRO1073;
Organism Homo sapiens (Human)

PRO ID PR:Q9UK58
DAG View
PRO Name cyclin-L1 (human)
Definition A cyclin-L1 that is encoded in the genome of human.
Short Label hCCNL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UK58 (CCNL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T30 Phosphorylation PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
T33 Phosphorylation PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
S65 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935, 18220336
T67 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S166 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
Y289 Phosphorylation PhosphoSitePlus
T325 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S329 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T330 Phosphorylation PhosphoSitePlus
S335 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231, ...17081983
S338 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 19690332, ...17081983
S341 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S342 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935
S352 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 19690332, 20068231
S355 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935
S372 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y376 Phosphorylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
T421 Phosphorylation PhosphoSitePlus
Y422 Phosphorylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus   UniProt 20068231
K449 Acetylation PhosphoSitePlus
K451 Acetylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
R471 Methylation PhosphoSitePlus
R473 Methylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus
K512 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S65 Phosphorylation HPRD 15302935, 18452278
T325 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231
S329 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231
T330 Phosphorylation HPRD 17081983, 20068231
S335 Phosphorylation HPRD 19413330, 19664995, 18452278, ...19651622, 18669648, 19415658, 20068231
S338 Phosphorylation HPRD 19413330, 17081983, 18452278, ...18669648, 19415658, 20068231
S341 Phosphorylation HPRD 19413330, 17081983, 19664995, ...18452278, 19651622, 18669648, 19415658, 20068231
S342 Phosphorylation HPRD 19413330, 17081983, 19664995, ...18452278, 19651622, 18669648, 20068231
S352 Phosphorylation HPRD 17322306, 18578522, 18767875, ...20058876, 19664995, 19007248, 19651622, 18669648, 18452278, 19415658, 20068231
S355 Phosphorylation HPRD 18669648, 15302935
S372 Phosphorylation HPRD 19664995
S374 Phosphorylation HPRD 20068231
S401 Phosphorylation HPRD 19651622
S403 Phosphorylation HPRD 19651622
S405 Phosphorylation HPRD 19651622
S445 Phosphorylation HPRD 19651622, 18767875, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S65 L65 Biomuta DOID:1324 / lung cancer [ cosmic ]
S65 W65 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S166 R166 Biomuta DOID:3571 / liver cancer [ icgc ]
S355 F355 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S355 A355 Biomuta DOID:1909 / melanoma [ tcga ]
S401 * Biomuta DOID:3571 / liver cancer [ icgc ]
S419 Y419 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K449 N449 Biomuta DOID:1324 / lung cancer [ cosmic ]
S470 Y470 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc ]
R471 C471 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:1909 / melanoma [ icgc, tcga ]
R473 Q473 Biomuta DOID:363 / uterine cancer [ tcga ]
K487 T487 Biomuta DOID:1909 / melanoma [ cosmic ]