iPTMnet Report for Q9UK32 (RPS6KA6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UK32 / KS6A6_HUMAN
Protein Name Ribosomal protein S6 kinase alpha-6
Gene Name Name: RPS6KA6
Synonyms:RSK4;
Organism Homo sapiens (Human)

PRO ID PR:Q9UK32
DAG View
PRO Name ribosomal protein S6 kinase alpha-6 (human)
Definition A ribosomal protein S6 kinase alpha-6 that is encoded in the genome of human.
Short Label hRPS6KA6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UK32 (RPS6KA6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S83 Phosphorylation PhosphoSitePlus
K86 Acetylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
K105 Acetylation PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
Y149 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
Y231 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S232 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15632195
T236 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y239 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K348 Acetylation PhosphoSitePlus
K367 Acetylation PhosphoSitePlus
S372 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15632195
S378 Phosphorylation PhosphoSitePlus
K386 Acetylation PhosphoSitePlus
S389 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15632195, 21406692
Y437 Phosphorylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
Y474 Phosphorylation PhosphoSitePlus
T482 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
Y525 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
T581 Phosphorylation PhosphoSitePlus   UniProt 15632195
T710 Phosphorylation PhosphoSitePlus
Y711 Phosphorylation PhosphoSitePlus
T715 Phosphorylation PhosphoSitePlus
T718 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
S736 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y231 Phosphorylation HPRD 18669648
S232 Phosphorylation HPRD   PRO 15632195, 18669648
T236 Phosphorylation HPRD 18669648
Y239 Phosphorylation HPRD 18669648
S372 Phosphorylation HPRD   PRO 15632195
S389 Phosphorylation HPRD   PRO 15632195
T581 Phosphorylation PRO 15632195


Q9UK32 (RPS6KA6) as PTM Enzyme



Substrate Site Score Source PMID
Q15831 (STK11) S428 neXtProt 11297520


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049133 (hRPS6KA6/Phos:1) pS232,pS372,pS389,pT581 PRO 15632195


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S83 * Biomuta DOID:363 / uterine cancer [ cosmic ]
K105 N105 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K108 N108 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S220 N220 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S232 L232 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ] DOID:263 / kidney cancer [ cosmic ]
K367 N367 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S372 Y372 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S372 F372 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K386 I386 Biomuta DOID:4159 / skin cancer [ cosmic ]
S389 I389 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S389 G389 Biomuta DOID:1319 / brain cancer [ cosmic ]
S736 N736 Biomuta DOID:1324 / lung cancer [ cosmic ]