iPTMnet Report for Q9UJM3 (ERRFI1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UJM3 / ERRFI_HUMAN
Protein Name ERBB receptor feedback inhibitor 1
Gene Name Name: ERRFI1
Synonyms:MIG6;
Organism Homo sapiens (Human)

PRO ID PR:Q9UJM3
DAG View
PRO Name ERBB receptor feedback inhibitor 1 (human)
Definition An ERBB receptor feedback inhibitor 1 that is encoded in the genome of human.
Short Label hERRFI1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UJM3 (ERRFI1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
Y33 Phosphorylation PhosphoSitePlus
Y54 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
K116 Acetylation PhosphoSitePlus
T119 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
T127 Phosphorylation PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus
Y224 Phosphorylation PhosphoSitePlus
S249 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18707149
S251 Phosphorylation HPRD   IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 22505024, ...18669648, 24275569, 18707149
S251 Phosphorylation O14757 (CHEK1) neXtProt   PhosphoSitePlus 22505024
S256 Phosphorylation PhosphoSitePlus   RLIMS-P 29196224
S265 Phosphorylation PhosphoSitePlus
S273 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 24275569
S276 Phosphorylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus 22505024
S302 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 22505024
S326 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
Y341 Phosphorylation PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus
Y394 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 17016520, 29574142, 24004111, ...18083107, 22975324, 26280531
Y395 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+ 18083107, 26280531
Y395 Phosphorylation P12931 (SRC) RLIMS-P+ 26280531
Y403 Phosphorylation PhosphoSitePlus
Y407 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
Y458 Phosphorylation PhosphoSitePlus
S461 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 21406692


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9UJM3 (ERRFI1) Y394 P00533 (EGFR) unknown eFIP 26280531


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 L2 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K116 * Biomuta DOID:3571 / liver cancer [ cosmic ]
T119 K119 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T131 A131 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S136 F136 Biomuta DOID:1319 / brain cancer [ icgc ]
S136 P136 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S251 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S265 F265 Biomuta DOID:1324 / lung cancer [ cosmic ]
S390 N390 Biomuta DOID:1319 / brain cancer [ cosmic ]
S391 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S457 F457 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S461 F461 Biomuta DOID:4159 / skin cancer [ cosmic ]