iPTMnet Report for Q9UJA5 (TRMT6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UJA5 / TRM6_HUMAN
Protein Name tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
Gene Name Name: TRMT6
Synonyms:KIAA1153,TRM6;ORFNames:CGI-09;
Organism Homo sapiens (Human)

PRO ID PR:Q9UJA5
DAG View
PRO Name tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (human)
Definition A tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6 that is encoded in the genome of human.
Short Label hTRMT6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UJA5 (TRMT6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K29 Ubiquitination PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
T92 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
T107 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
K112 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K145 Methylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
Y154 Phosphorylation PhosphoSitePlus
T159 Phosphorylation PhosphoSitePlus
T165 Phosphorylation PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
Y173 Phosphorylation PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
Y231 Phosphorylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus   UniProt 23186163
S305 Phosphorylation PhosphoSitePlus   UniProt 23186163
S325 Phosphorylation PhosphoSitePlus
Y342 Phosphorylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
R417 Methylation PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
T476 Phosphorylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T107 Phosphorylation HPRD 17525332, 18077418
S164 Phosphorylation HPRD 20068231
T165 Phosphorylation HPRD 20068231
Y172 Phosphorylation HPRD 20068231
Y173 Phosphorylation HPRD 20068231
S325 Phosphorylation HPRD 18077418


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T87 N87 Biomuta DOID:3571 / liver cancer [ cosmic ]
T193 M193 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T291 S291 Biomuta DOID:1324 / lung cancer [ cosmic ]
S325 Y325 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S325 C325 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
R417 S417 Biomuta [ cosmic ]