iPTMnet Report for Q9UJA3 (MCM8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UJA3 / MCM8_HUMAN
Protein Name DNA helicase MCM8
Gene Name Name: MCM8
Synonyms:C20orf154;
Organism Homo sapiens (Human)

PRO ID PR:Q9UJA3
DAG View
PRO Name DNA helicase MCM8 (human)
Definition A DNA helicase MCM8 that is encoded in the genome of human.
Short Label hMCM8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UJA3 (MCM8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R6 Methylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
Y86 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
Y201 Phosphorylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
Y214 Phosphorylation PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
Y218 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
T236 Phosphorylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
T619 Phosphorylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus   UniProt 23186163
K644 Ubiquitination PhosphoSitePlus
K651 Ubiquitination PhosphoSitePlus
K668 Ubiquitination PhosphoSitePlus
S715 Phosphorylation PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K60 N60 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K118 R118 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
Y199 H199 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K208 M208 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y218 C218 Biomuta DOID:5041 / esophageal cancer [ cosmic ]