iPTMnet Report for Q9UJ83 (HACL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UJ83 / HACL1_HUMAN
Protein Name 2-hydroxyacyl-CoA lyase 1
Gene Name Name: HACL1
Synonyms:HPCL,HPCL2,PHYH2;ORFNames:HSPC279;
Organism Homo sapiens (Human)

PRO ID PR:Q9UJ83
DAG View
PRO Name 2-hydroxyacyl-CoA lyase 1 (human)
Definition A 2-hydroxyacyl-CoA lyase 1 that is encoded in the genome of human.
Short Label hHACL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UJ83 (HACL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus   UniProt 23186163
K18 Ubiquitination PhosphoSitePlus
C64 Methylation IEDB 31844290
C80 Methylation IEDB 31844290
T135 Phosphorylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
C204 Methylation IEDB 31844290
K214 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
Y240 Phosphorylation IEDB 32387766
K241 Acetylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
T247 Phosphorylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
Y260 Phosphorylation PhosphoSitePlus
S359 O-Glycosylation GlyGen 30379171
K365 Ubiquitination PhosphoSitePlus
Y377 Phosphorylation PhosphoSitePlus
Y382 Phosphorylation PhosphoSitePlus
Y412 Phosphorylation PhosphoSitePlus
T422 Phosphorylation PhosphoSitePlus
T425 Phosphorylation PhosphoSitePlus
C469 Methylation IEDB 31844290
Y486 Phosphorylation PhosphoSitePlus
C511 Methylation IEDB 31844290
K540 Acetylation PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
T549 Phosphorylation PhosphoSitePlus
T550 Phosphorylation PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K18 N18 Biomuta DOID:4159 / skin cancer [ cosmic ]
K18 E18 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S138 F138 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y412 H412 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S553 F553 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]