iPTMnet Report for Q9UJ41 (RABGEF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UJ41 / RABX5_HUMAN
Protein Name Rab5 GDP/GTP exchange factor
Gene Name Name: RABGEF1
Synonyms:RABEX5;
Organism Homo sapiens (Human)

PRO ID PR:Q9UJ41
DAG View
PRO Name Rab5 GDP/GTP exchange factor (human)
Definition A Rab5 GDP/GTP exchange factor that is encoded in the genome of human.
Short Label hRABGEF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UJ41 (RABGEF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K49 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K103 Sumoylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
K115 Sumoylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
T131 Phosphorylation PhosphoSitePlus
S132 Phosphorylation IEDB   PhosphoSitePlus   UniProt 30784271, 24275569
T135 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K151 Acetylation PhosphoSitePlus   UniProt 19608861
K151 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K170 Acetylation PhosphoSitePlus   UniProt 19608861
K170 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K213 Acetylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K303 Sumoylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus   UniProt 20068231
S377 Phosphorylation PhosphoSitePlus   UniProt 20068231
S386 Phosphorylation PhosphoSitePlus
T389 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus   UniProt 23186163
K408 Ubiquitination PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
Y456 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S124 Phosphorylation HPRD 18691976, 18669648
S132 Phosphorylation HPRD 18088087, 17081983, 20068231
T135 Phosphorylation HPRD 20068231
S373 Phosphorylation HPRD 20068231
S377 Phosphorylation HPRD 20068231
Y384 Phosphorylation HPRD 18691976, 18669648
S386 Phosphorylation HPRD 18669648, 20068231
T389 Phosphorylation HPRD 18691976, 18669648, 20068231
S390 Phosphorylation HPRD 18669648, 20068231
S400 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S108 Y108 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S108 F108 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K115 E115 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S124 T124 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T131 I131 Biomuta DOID:4159 / skin cancer [ cosmic ]
T135 A135 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K206 N206 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K287 Q287 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y384 H384 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y384 C384 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K408 T408 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y456 C456 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]