iPTMnet Report for Q9UIS9 (MBD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UIS9 / MBD1_HUMAN
Protein Name Methyl-CpG-binding domain protein 1
Gene Name Name: MBD1
Synonyms:CXXC3,PCM1;
Organism Homo sapiens (Human)

PRO ID PR:Q9UIS9
DAG View
PRO Name methyl-CpG-binding domain protein 1 (human)
Definition A methyl-CpG-binding domain protein 1 that is encoded in the genome of human.
Short Label hMBD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UIS9 (MBD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation PhosphoSitePlus
K46 Sumoylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
Y52 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
K75 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
T116 Phosphorylation PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
K277 Sumoylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
S295 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S297 Phosphorylation PhosphoSitePlus   UniProt 24275569
T301 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S311 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
S391 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S393 Phosphorylation PhosphoSitePlus
S399 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
Y403 Phosphorylation PhosphoSitePlus
S411 Phosphorylation IEDB 30784271
K422 Acetylation PhosphoSitePlus
K422 Sumoylation PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
K499 Sumoylation PhosphoSitePlus
K502 Sumoylation PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
T505 Phosphorylation PhosphoSitePlus
K538 Sumoylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
T570 Phosphorylation PhosphoSitePlus
T574 Phosphorylation PhosphoSitePlus
T587 Phosphorylation PhosphoSitePlus
R593 Methylation PhosphoSitePlus
K595 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S295 Phosphorylation HPRD 17525332
S297 Phosphorylation HPRD 17081983
T301 Phosphorylation HPRD 17525332
S391 Phosphorylation HPRD 18669648
S393 Phosphorylation HPRD 20068231
S399 Phosphorylation HPRD 18669648
T505 Phosphorylation HPRD 18077418
T570 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S262 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S311 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S368 Phosphorylation HPRD 18669648
S370 Phosphorylation HPRD 20068231
S376 Phosphorylation HPRD 18669648
T501 Phosphorylation HPRD 20068231
S565 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S295 Phosphorylation HPRD 17525332
S297 Phosphorylation HPRD 17081983
T301 Phosphorylation HPRD 17525332
S311 Phosphorylation PhosphoSitePlus
S335 Phosphorylation HPRD 18669648
S343 Phosphorylation HPRD 18669648
T468 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K172 Methylation PhosphoSitePlus
S246 Phosphorylation HPRD 17525332
S248 Phosphorylation HPRD 17081983
T252 Phosphorylation HPRD 17525332
S342 Phosphorylation HPRD 18669648
S344 Phosphorylation HPRD 20068231
S350 Phosphorylation HPRD 18669648
T456 Phosphorylation HPRD 18077418
T521 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S295 Phosphorylation HPRD 17525332
S297 Phosphorylation HPRD 17081983
T301 Phosphorylation HPRD 17525332
S335 Phosphorylation HPRD 18669648
S343 Phosphorylation HPRD 18669648
T449 Phosphorylation HPRD 18077418
T514 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y52 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K109 N109 Biomuta [ cosmic ]
K172 N172 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S343 L343 Biomuta DOID:4159 / skin cancer [ cosmic ]
S350 L350 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ]
S376 L376 Biomuta DOID:4159 / skin cancer [ cosmic ]
S399 L399 Biomuta DOID:4159 / skin cancer [ cosmic ]
S565 L565 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]