iPTMnet Report for Q9UIQ6 (LNPEP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UIQ6 / LCAP_HUMAN
Protein Name Leucyl-cystinyl aminopeptidase
Gene Name Name: LNPEP
Synonyms:OTASE;
Organism Homo sapiens (Human)

PRO ID PR:Q9UIQ6
DAG View
PRO Name leucyl-cystinyl aminopeptidase (human)
Definition A leucyl-cystinyl aminopeptidase that is encoded in the genome of human.
Short Label hLNPEP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UIQ6 (LNPEP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S19 Phosphorylation PhosphoSitePlus
Y46 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
Y70 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
S80 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S91 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T93 Phosphorylation PhosphoSitePlus
Y95 Phosphorylation PhosphoSitePlus
C134 Methylation IEDB 31844290
N145 N-Glycosylation GlyGen 24190977
S147 O-Glycosylation GlyGen 34019948, 35289036
K159 Ubiquitination PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
N184 N-Glycosylation GlyGen   UniProt 23090970, 24190977, 19349973
N256 N-Glycosylation GlyGen 24190977
K286 Acetylation IEDB 34357683
K287 Acetylation IEDB 34357683
K287 Ubiquitination PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
N374 N-Glycosylation GlyGen 24190977
N448 N-Glycosylation GlyGen   UniProt 24190977, 19349973
S506 Phosphorylation PhosphoSitePlus
Y508 Phosphorylation PhosphoSitePlus
N525 N-Glycosylation GlyGen 24190977
K608 Ubiquitination PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
Y665 Phosphorylation PhosphoSitePlus
S666 Phosphorylation PhosphoSitePlus
Y668 Phosphorylation PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
N682 N-Glycosylation GlyGen   UniProt 24190977, 19349973
K691 Acetylation PhosphoSitePlus
Y784 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
N831 N-Glycosylation GlyGen 24190977
N834 N-Glycosylation GlyGen 29741879, 24190977
N850 N-Glycosylation GlyGen   UniProt 29741879, 24190977, 19349973
S886 Phosphorylation PhosphoSitePlus
R904 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y70 Phosphorylation HPRD 19901323
S80 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y56 Phosphorylation HPRD 19901323


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y46 H46 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T93 A93 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
N145 K145 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S147 P147 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K159 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S329 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S506 C506 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
N525 H525 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S678 T678 Biomuta DOID:10534 / stomach cancer [ icgc ]
S789 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
R904 Q904 Biomuta DOID:3571 / liver cancer [ cosmic ]