iPTMnet Report Q9UIK4 DAPK2

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9UIK4 / DAPK2_HUMAN
Protein Name	Death-associated protein kinase 2
Gene Name	Name: DAPK2
Organism	Homo sapiens (Human)

PRO ID	PR:Q9UIK4 DAG View
PRO Name	death-associated protein kinase 2 (human)
Definition	A death-associated protein kinase 2 that is encoded in the genome of human.
Short Label	hDAPK2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9UIK4 (DAPK2) as Substrate

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S8	Phosphorylation		score1	PhosphoSitePlus
	Y49	Phosphorylation		score1	PhosphoSitePlus
	K151	Ubiquitination		score1	PhosphoSitePlus
	T275	Phosphorylation		score1	PhosphoSitePlus
	S299	Phosphorylation		score4	neXtProt PhosphoSitePlus RLIMS-P UniProt	22580283, 23186163
	S299	Phosphorylation	Q13976 (PRKG1)	score2	neXtProt	22580283
	S318	Phosphorylation		score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	11230133, 34413451
	S318	Phosphorylation	Q9UIK4 (DAPK2)	score3	neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	11230133
	S320	Phosphorylation		score1	PhosphoSitePlus
	K335	Ubiquitination		score1	PhosphoSitePlus
	S349	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163, 17081983
	S367	Phosphorylation		score3	neXtProt PhosphoSitePlus RLIMS-P	22580283
	S367	Phosphorylation	Q13976 (PRKG1)	score2	neXtProt	22580283
	S368	Phosphorylation		score3	neXtProt PhosphoSitePlus RLIMS-P	22580283
	S368	Phosphorylation	Q13976 (PRKG1)	score2	neXtProt	22580283
	T369	Phosphorylation		score4	PhosphoSitePlus RLIMS-P UniProt	26047703, 34413451

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S299	Phosphorylation		score0	HPRD	20166139
	S318	Phosphorylation		score1	HPRD	11230133
	S318	Phosphorylation	Q9UIK4 (DAPK2)	score1	HPRD	11230133
	S349	Phosphorylation		score0	HPRD	18669648, 17081983

Q9UIK4 (DAPK2) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	Q8N122 (RPTOR)	S721	score2	RLIMS-P+	25361081
	Q9UIK4 (DAPK2)	S318	score3	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	11230133

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
Y49	H49	Biomuta		DOID:10534 / stomach cancer [ cosmic, icgc ]
S368	R368	Biomuta		DOID:10534 / stomach cancer [ cosmic ]