iPTMnet Report for Q9UII4 (HERC5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UII4 / HERC5_HUMAN
Protein Name E3 ISG15--protein ligase HERC5
Gene Name Name: HERC5
Synonyms:CEB1,CEBP1;
Organism Homo sapiens (Human)

PRO ID PR:Q9UII4
DAG View
PRO Name E3 ISG15--protein ligase HERC5 (human)
Definition An E3 ISG15--protein ligase HERC5 that is encoded in the genome of human.
Short Label hHERC5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UII4 (HERC5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K19 Ubiquitination PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
C58 Methylation IEDB 31844290
K117 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
S357 O-Glycosylation GlyGen 30379171, 31492838
S370 Phosphorylation PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
K541 Sumoylation PhosphoSitePlus
C552 Methylation IEDB 31844290
K643 Ubiquitination PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
Y661 Phosphorylation PhosphoSitePlus
K795 Ubiquitination PhosphoSitePlus
K807 Ubiquitination PhosphoSitePlus
S810 Phosphorylation PhosphoSitePlus
K867 Ubiquitination PhosphoSitePlus
Y868 Phosphorylation HPRD 18452278
Y871 Phosphorylation HPRD 18452278
K890 Ubiquitination PhosphoSitePlus
K898 Ubiquitination PhosphoSitePlus
K906 Ubiquitination PhosphoSitePlus
K918 Ubiquitination PhosphoSitePlus
K946 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K19 T19 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K458 N458 Biomuta DOID:9256 / colorectal cancer [ icgc ]
C552 * Biomuta DOID:1324 / lung cancer [ cosmic ]
C552 S552 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K795 T795 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S810 T810 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S810 I810 Biomuta DOID:10283 / prostate cancer [ cosmic ]