iPTMnet Report for Q9UI10 (EIF2B4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UI10 / EI2BD_HUMAN
Protein Name Translation initiation factor eIF-2B subunit delta
Gene Name Name: EIF2B4
Synonyms:EIF2BD;
Organism Homo sapiens (Human)

PRO ID PR:Q9UI10
DAG View
PRO Name translation initiation factor eIF-2B subunit delta (human)
Definition A translation initiation factor eIF-2B subunit delta that is encoded in the genome of human.
Short Label hEIF2B4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UI10 (EIF2B4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S12 Phosphorylation PhosphoSitePlus   UniProt 23186163
C69 S-Nitrosylation dbSNO 26338901
T86 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S130 Phosphorylation PhosphoSitePlus   UniProt 23186163
T137 Phosphorylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
Y186 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
Y214 Phosphorylation PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
R374 Methylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
Y385 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
C444 Methylation IEDB 31844290
C465 S-Nitrosylation dbSNO 26338901
K466 Acetylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T86 Phosphorylation HPRD 18669648, 20068231
S130 Phosphorylation HPRD 18691976, 19007248, 19691289
S132 Phosphorylation HPRD 20068231
T137 Phosphorylation HPRD 19413330, 19007248
Site PTM Type PTM Enzyme Score Source PMID
S86 Phosphorylation PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
T106 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S150 Phosphorylation HPRD 18691976, 19007248, 19691289
S152 Phosphorylation HPRD 20068231
T157 Phosphorylation HPRD 19413330, 19007248
Site PTM Type PTM Enzyme Score Source PMID
T85 Phosphorylation HPRD 18669648, 20068231
S129 Phosphorylation HPRD 18691976, 19007248, 19691289
S131 Phosphorylation HPRD 20068231
T136 Phosphorylation HPRD 19413330, 19007248


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S100 W100 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S129 T129 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S130 T130 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T136 P136 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T137 P137 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S150 T150 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T157 P157 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K176 E176 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y186 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S187 R187 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K291 T291 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R374 C374 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S384 F384 Biomuta DOID:4159 / skin cancer [ cosmic ]