iPTMnet Report for Q9UI08 (EVL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UI08 / EVL_HUMAN
Protein Name Ena/VASP-like protein
Gene Name Name: EVL
Synonyms:RNB6;
Organism Homo sapiens (Human)

PRO ID PR:Q9UI08
DAG View
PRO Name ena/VASP-like protein (human)
Definition An ena/VASP-like protein that is encoded in the genome of human.
Short Label hEVL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UI08 (EVL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y16 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
Y39 Phosphorylation PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
S170 Phosphorylation IEDB 32387766
S171 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
S246 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S248 Phosphorylation phospho.ELM 18669648
T250 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K252 Ubiquitination PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus
S304 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S306 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S313 Phosphorylation PhosphoSitePlus
S329 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935
S331 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935
K334 Acetylation IEDB 34357683
S337 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus   UniProt 19690332
T343 Phosphorylation PhosphoSitePlus
S345 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S349 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19367720, 18669648, 24275569
S354 Phosphorylation PhosphoSitePlus   UniProt 19690332
S358 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus   UniProt 19367720, 23186163, 24275569
K399 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S160 Phosphorylation HPRD 10945997
S248 Phosphorylation HPRD 18669648, 20068231
S250 Phosphorylation HPRD 18669648
T252 Phosphorylation HPRD 18669648, 17924679
S261 Phosphorylation HPRD 20068231
S306 Phosphorylation HPRD 18669648
S308 Phosphorylation HPRD 18669648
S320 Phosphorylation HPRD 20068231
S321 Phosphorylation HPRD 20068231
S331 Phosphorylation HPRD 20166139, 18669648, 15302935, ...20230923
S333 Phosphorylation HPRD 20230923, 18767875, 15302935, ...18452278, 18669648, 20068231
S347 Phosphorylation HPRD 18669648
S351 Phosphorylation HPRD 18669648
S356 Phosphorylation HPRD 20068231
S371 Phosphorylation HPRD 20166139, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S158 L158 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S160 L160 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S329 N329 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S329 C329 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S331 L331 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S331 N331 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S331 C331 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S333 L333 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S337 F337 Biomuta [ cosmic ]
S341 F341 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S349 N349 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S351 N351 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S358 L358 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S362 P362 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]