Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UHX1 / PUF60_HUMAN
Protein Name Poly(U)-binding-splicing factor PUF60
Gene Name Name: PUF60
Synonyms:FIR;
Organism Homo sapiens (Human)

PRO ID PR:Q9UHX1
DAG View
PRO Name poly(U)-binding-splicing factor PUF60 (human)
Definition A poly(U)-binding-splicing factor PUF60 that is encoded in the genome of human.
Short Label hPUF60
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UHX1 (PUF60) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation PhosphoSitePlus
T5 Phosphorylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K43 Sumoylation PhosphoSitePlus
T60 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...20068231
K69 Ubiquitination PhosphoSitePlus
K72 Methylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
Y73 Phosphorylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus   UniProt 20068231
S116 Phosphorylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
S206 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S238 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
K251 Acetylation PhosphoSitePlus   UniProt 19608861
K251 Ubiquitination PhosphoSitePlus
T262 Phosphorylation PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
T304 Phosphorylation PhosphoSitePlus
T311 Phosphorylation PhosphoSitePlus
T314 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S406 Phosphorylation PhosphoSitePlus
K454 Acetylation PhosphoSitePlus   UniProt 19608861
K454 Ubiquitination PhosphoSitePlus
K458 Sumoylation PhosphoSitePlus
T462 Phosphorylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
Y547 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation HPRD 18491316
T60 Phosphorylation HPRD 19413330, 18669648, 20068231
S112 Phosphorylation HPRD 20068231
S206 Phosphorylation HPRD 18669648
T311 Phosphorylation HPRD 20068231
T314 Phosphorylation HPRD 18669648, 20068231
S406 Phosphorylation HPRD 20058876
Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation HPRD 18491316
T60 Phosphorylation HPRD 19413330, 18669648, 20068231
T87 Phosphorylation PhosphoSitePlus
S189 Phosphorylation HPRD 18669648
T294 Phosphorylation HPRD 20068231
T297 Phosphorylation HPRD 18669648, 20068231
S389 Phosphorylation HPRD 20058876
Site PTM Type PTM Enzyme Score Source PMID
K14 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K14 Sumoylation PhosphoSitePlus
T58 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T60 A60 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S112 * Biomuta DOID:11934 / head and neck cancer [ tcga ]
Y177 C177 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K489 N489 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S558 C558 Biomuta DOID:1612 / breast cancer [ cosmic ]