iPTMnet Report for Q9UHX1 (PUF60)
Protein Information
| UniProt AC / UniProt ID | Q9UHX1 / PUF60_HUMAN |
| Protein Name | Poly(U)-binding-splicing factor PUF60 |
| Gene Name | Name: PUF60 Synonyms:FIR; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9UHX1 |
| PRO Name | poly(U)-binding-splicing factor PUF60 (human) |
| Definition | A poly(U)-binding-splicing factor PUF60 that is encoded in the genome of human. |
| Short Label | hPUF60 |
| Category | organism-gene |
Q9UHX1 (PUF60) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T3 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T5 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K34 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K43 | Sumoylation | score1 | PhosphoSitePlus | |||
| T60 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 16964243, ... | ||
| K69 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K72 | Methylation | score1 | PhosphoSitePlus | |||
| K72 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y73 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K80 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S112 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 20068231 | ||
| S116 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C129 | Methylation | score1 | IEDB | 31844290 | ||
| K168 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y177 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K201 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S206 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| S238 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K243 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S244 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K251 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K251 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T262 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T263 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K267 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y274 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S280 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K301 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T304 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T311 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T314 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 20068231 | ||
| S406 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K454 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K454 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K458 | Sumoylation | score1 | PhosphoSitePlus | |||
| T462 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K489 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K541 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y547 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S555 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S558 | Phosphorylation | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T3 | Phosphorylation | score0 | HPRD | 18491316 | ||
| T60 | Phosphorylation | score0 | HPRD | 19413330, 18669648, 20068231 | ||
| S112 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S206 | Phosphorylation | score0 | HPRD | 18669648 | ||
| T311 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T314 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S406 | Phosphorylation | score0 | HPRD | 20058876 |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T3 | Phosphorylation | score0 | HPRD | 18491316 | ||
| T60 | Phosphorylation | score0 | HPRD | 19413330, 18669648, 20068231 | ||
| T87 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S189 | Phosphorylation | score0 | HPRD | 18669648 | ||
| T294 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T297 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S389 | Phosphorylation | score0 | HPRD | 20058876 |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| K14 | Sumoylation | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| K14 | Sumoylation | score1 | PhosphoSitePlus | |||
| T58 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K34 | N34 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| T60 | A60 | Biomuta | DOID:4362 / cervical cancer [ cosmic ] | |
| T60 | M60 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S112 | * | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| K168 | N168 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| Y177 | C177 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S189 | R189 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S206 | R206 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S389 | N389 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
| S406 | N406 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K489 | N489 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S558 | C558 | Biomuta | DOID:1612 / breast cancer [ cosmic ] |
DAG View