iPTMnet Report for Q9UHW9 (SLC12A6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UHW9 / S12A6_HUMAN
Protein Name Solute carrier family 12 member 6
Gene Name Name: SLC12A6
Synonyms:KCC3;
Organism Homo sapiens (Human)

PRO ID PR:Q9UHW9
DAG View
PRO Name solute carrier family 12 member 6 (human)
Definition A solute carrier family 12 member 6 that is encoded in the genome of human.
Short Label hSLC12A6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UHW9 (SLC12A6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19665974, 19690332
S47 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
S96 Phosphorylation Q9BYP7 (WNK3) , Q9UEW8 (STK39) PhosphoSitePlus   RLIMS-P   Signor 24043619, 24393035
Y116 Phosphorylation phospho.ELM 18669648
S120 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y122 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y156 Phosphorylation PhosphoSitePlus
T160 Phosphorylation Q9UEW8 (STK39) PhosphoSitePlus 24393035
K164 Ubiquitination PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus
N379 N-Glycosylation GlyGen 24190977
N398 N-Glycosylation GlyGen 29741879
K460 Acetylation PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
K464 Acetylation PhosphoSitePlus
K600 Acetylation PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
K724 Ubiquitination PhosphoSitePlus
S736 Phosphorylation UniProt 34031912
K772 Ubiquitination PhosphoSitePlus
T778 Phosphorylation PhosphoSitePlus   UniProt 34031912
S781 Phosphorylation PhosphoSitePlus
K784 Ubiquitination PhosphoSitePlus
S940 Phosphorylation PhosphoSitePlus
S981 Phosphorylation UniProt 34031912
T991 Phosphorylation Q9H4A3 (WNK1) , Q9BYP7 (WNK3) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24393035, 27485015, 34031912, ...24043619, 19665974, 26217182, 27782176
S1007 Phosphorylation PhosphoSitePlus
K1019 Ubiquitination PhosphoSitePlus
S1023 Phosphorylation PhosphoSitePlus   UniProt 19665974
T1028 Phosphorylation PhosphoSitePlus
S1029 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19665974
S1032 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
T1048 Phosphorylation Q9UEW8 (STK39) , Q9H4A3 (WNK1) , Q9BYP7 (WNK3) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24393035, 24043619, 19665974, ...26217182, 27782176
K1063 Ubiquitination PhosphoSitePlus
S1064 Phosphorylation PhosphoSitePlus
K1097 Ubiquitination PhosphoSitePlus
Y1121 Phosphorylation UniProt 34031912
T1129 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S32 Phosphorylation HPRD 18578522
Y116 Phosphorylation HPRD 18669648
S120 Phosphorylation HPRD 18669648
S1029 Phosphorylation HPRD 18669648
S1032 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
T47 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
Y65 Phosphorylation HPRD 18669648
S69 Phosphorylation HPRD 18669648
S978 Phosphorylation HPRD 18669648
S981 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S32 Phosphorylation HPRD 18578522
Y101 Phosphorylation HPRD 18669648
S105 Phosphorylation HPRD 18669648
S1014 Phosphorylation HPRD 18669648
S1017 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation HPRD 18578522
Y107 Phosphorylation HPRD 18669648
S111 Phosphorylation HPRD 18669648
S1020 Phosphorylation HPRD 18669648
S1023 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y57 Phosphorylation HPRD 18669648
S61 Phosphorylation HPRD 18669648
S970 Phosphorylation HPRD 18669648
S973 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S29 P29 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K30 Q30 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S45 P45 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S96 P96 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K600 N600 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T778 S778 Biomuta DOID:1324 / lung cancer [ cosmic ]
S781 L781 Biomuta DOID:4606 / bile duct cancer [ cosmic ]