iPTMnet Report for Q9UHP3 (USP25)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UHP3 / UBP25_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 25
Gene Name Name: USP25
Synonyms:USP21;
Organism Homo sapiens (Human)

PRO ID PR:Q9UHP3
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 25 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 25 that is encoded in the genome of human.
Short Label hUSP25
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UHP3 (USP25) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
Y69 Phosphorylation PhosphoSitePlus
Y70 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus   UniProt 23186163
K99 Sumoylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus   UniProt 19440361
S113 Phosphorylation PhosphoSitePlus
K141 Sumoylation PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
T149 Phosphorylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
Y404 Phosphorylation PhosphoSitePlus
Y425 Phosphorylation PhosphoSitePlus
T427 Phosphorylation PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
K630 Ubiquitination PhosphoSitePlus
K669 Ubiquitination PhosphoSitePlus
T680 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 25755282
T680 Phosphorylation Q86Y07 (VRK2) PhosphoSitePlus   Signor 25755282
K698 Ubiquitination PhosphoSitePlus
K710 Ubiquitination PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
K721 Ubiquitination PhosphoSitePlus
T727 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 25755282
T727 Phosphorylation Q86Y07 (VRK2) PhosphoSitePlus   Signor 25755282
Y740 Phosphorylation PhosphoSitePlus   UniProt 19909739
S745 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 25755282
S745 Phosphorylation Q86Y07 (VRK2) PhosphoSitePlus   Signor 25755282
K782 Ubiquitination PhosphoSitePlus
K845 Ubiquitination PhosphoSitePlus
K850 Ubiquitination PhosphoSitePlus
S912 Phosphorylation PhosphoSitePlus
Y916 Phosphorylation PhosphoSitePlus
K1011 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y916 Phosphorylation HPRD 17924679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y69 H69 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S85 G85 Biomuta DOID:363 / uterine cancer [ icgc ]
K254 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K313 N313 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K313 Q313 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K388 N388 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T427 M427 Biomuta DOID:3571 / liver cancer [ cosmic ]
K669 E669 Biomuta DOID:1324 / lung cancer [ cosmic ]
T680 K680 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K698 Q698 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K710 E710 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K782 Q782 Biomuta DOID:363 / uterine cancer [ icgc ]