iPTMnet Report for Q9UHD9 (UBQLN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UHD9 / UBQL2_HUMAN
Protein Name Ubiquilin-2
Gene Name Name: UBQLN2
Synonyms:N4BP4,PLIC2;ORFNames:HRIHFB2157;
Organism Homo sapiens (Human)

PRO ID PR:Q9UHD9
DAG View
PRO Name ubiquilin-2 (human)
Definition A ubiquilin-2 that is encoded in the genome of human.
Short Label hUBQLN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UHD9 (UBQLN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
S8 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
S104 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 36240223, 34105348
S112 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 31373491, 34105348, 36240223
T113 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...35138101, 35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 31373491, 34105348, 36240223
S116 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 31373491, 34105348, 36240223
T121 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 36240223, 34105348
T123 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 31373491, 34105348, 36240223
T123 Phosphorylation PhosphoSitePlus
T124 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 31373491, 34105348, 36240223
S125 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 36240223, 34105348
S127 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 36240223, 34105348
T128 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 36240223, 34105348
T128 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
R249 Methylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
R269 Methylation PhosphoSitePlus
T508 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 36240223, 34105348
T519 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 36240223, 34105348
S527 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 36240223, 34105348
T528 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 36240223, 34105348
S530 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 36240223, 34105348
S539 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 36240223, 34105348
T546 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 36240223, 34105348
T550 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 36240223, 34105348
S551 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 36240223, 34105348
S553 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...35254053, 31637018, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 29237092, 31492838, 29485866, 32119511, 35289036, 29351928, 36240223, 34105348


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K38 N38 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T39 A39 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S112 C112 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T113 P113 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T124 A124 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S222 N222 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S256 R256 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R269 W269 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T528 S528 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T546 I546 Biomuta DOID:3571 / liver cancer [ cosmic ]
S551 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S553 Y553 Biomuta DOID:363 / uterine cancer [ icgc ]