iPTMnet Report for Q9UHD2 (TBK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UHD2 / TBK1_HUMAN
Protein Name Serine/threonine-protein kinase TBK1
Gene Name Name: TBK1
Synonyms:NAK;
Organism Homo sapiens (Human)

PRO ID PR:Q9UHD2
DAG View
PRO Name serine/threonine-protein kinase TBK1 (human)
Definition A serine/threonine-protein kinase TBK1 that is encoded in the genome of human.
Short Label hTBK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UHD2 (TBK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K30 Acetylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus   UniProt 23453971
R54 Methylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
R134 Methylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
Y153 Phosphorylation PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
S172 Phosphorylation Q9UHD2 (TBK1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 30853401, 30021902, 11839743, ...18356163, 32772249, 27135603, 29379028, 21931631, 30867315, 32757223, 32514015, 29125880, 25815785, 29755980, 28159912, 25891802, 27538435, 28049762, 26376340, 31442668, 23746807, 30627666, 35406696, 28871090, 22750291, 22619329, 30033073, 25503978, 21145761, 35868534, 27935834, 24752990, 22851595, 19307177, 31379806
Y174 Phosphorylation PhosphoSitePlus
Y179 Phosphorylation PhosphoSitePlus   RLIMS-P 28049762
R228 Methylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K236 Acetylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K241 Acetylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
K251 Acetylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
Y325 Phosphorylation PhosphoSitePlus
Y340 Phosphorylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
Y354 Phosphorylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus   UniProt 23453971
K416 Ubiquitination PhosphoSitePlus
Y435 Phosphorylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
T503 Phosphorylation PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
S509 Phosphorylation HPRD 18691976
S511 Phosphorylation PhosphoSitePlus
S527 Phosphorylation Q92630 (DYRK2) PRO   PhosphoSitePlus   RLIMS-P 28676338, 26407194
K545 Ubiquitination PhosphoSitePlus
Y577 Phosphorylation PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
Y591 Phosphorylation PhosphoSitePlus
Y592 Phosphorylation PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
C605 Methylation IEDB 33981976, 31844290
K607 Acetylation PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
K646 Acetylation PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
Y647 Phosphorylation PhosphoSitePlus
Y650 Phosphorylation PhosphoSitePlus
K661 Ubiquitination PhosphoSitePlus
T664 Phosphorylation PhosphoSitePlus
K670 Ubiquitination UniProt 22388039, 27692986
T672 Phosphorylation HPRD 18691976
Y677 Phosphorylation PhosphoSitePlus
K691 Acetylation PhosphoSitePlus
K692 Acetylation PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
S716 Phosphorylation Q04759 (PRKCQ) HPRD   PhosphoSitePlus   Signor   UniProt 18691976, 31792381, 23186163


Q9UHD2 (TBK1) as PTM Enzyme



Substrate Site Score Source PMID
O14920 (IKBKB) S177 neXtProt 10783893
O14920 (IKBKB) S181 neXtProt 10783893
P03372 (ESR1) S305 PhosphoSitePlus 24449872
P06213 (INSR) S1033 neXtProt 19251743
P25963 (NFKBIA) S36 HPRD   Signor 8601309, 9721103, 11815618, ...10783893
P31749 (AKT1) T308 PhosphoSitePlus 21329883
P31749 (AKT1) S473 neXtProt   PhosphoSitePlus   Signor 21329883, 21106850, 21464307
P42226 (STAT6) S407 PhosphoSitePlus   Signor 22000020
P42226 (STAT6) Y641 Signor 22000020
P42858 (HTT) S13 Signor 32757223
Q01094 (E2F1) S332 PhosphoSitePlus 26724859
Q04206 (RELA) S536 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15489227
Q13501 (SQSTM1) S403 PhosphoSitePlus   RLIMS-P+   Signor 22921120, 25972374
Q13568 (IRF5) S158 PhosphoSitePlus   Signor 22412986
Q13568 (IRF5) S293 PhosphoSitePlus   Signor 22412986
Q14653 (IRF3) S173 neXtProt   PhosphoSitePlus 20511230
Q14653 (IRF3) S175 neXtProt   PhosphoSitePlus 20511230
Q14653 (IRF3) S385 neXtProt   phospho.ELM   PhosphoSitePlus 17526488, 20511230
Q14653 (IRF3) S386 neXtProt   phospho.ELM   PhosphoSitePlus 14703513, 17526488, 20511230
Q14653 (IRF3) S396 neXtProt   PhosphoSitePlus 18272581, 19153595, 17526488, ...20511230, 16914100
Q14653 (IRF3) S398 neXtProt   PhosphoSitePlus 19153595, 17526488, 16914100
Q14653 (IRF3) S402 neXtProt   PhosphoSitePlus 19153595, 17526488, 18272581, ...16914100
Q14653 (IRF3) T404 neXtProt   PhosphoSitePlus 19153595, 17526488
Q14653 (IRF3) S405 neXtProt   PhosphoSitePlus 19153595, 17526488
Q5S007 (LRRK2) S910 neXtProt 22723946
Q5S007 (LRRK2) S935 neXtProt 22723946
Q86WV6 (STING1) S358 neXtProt   PhosphoSitePlus   Signor 22394562, 18818105
Q92985 (IRF7) S471 PhosphoSitePlus 16914100
Q92985 (IRF7) S472 PhosphoSitePlus 16914100
Q92985 (IRF7) S477 neXtProt   PhosphoSitePlus   RLIMS-P+ 22787218, 16914100
Q92985 (IRF7) S479 neXtProt   PhosphoSitePlus   RLIMS-P+ 22787218, 16914100
Q96CV9 (OPTN) S177 neXtProt   PhosphoSitePlus 21617041, 26365381, 26376340, ...18307994, 21862579
Q96CV9 (OPTN) S473 PhosphoSitePlus   RLIMS-P+ 26365381, 27035970
Q96CV9 (OPTN) S513 PhosphoSitePlus 26365381
Q96FA3 (PELI1) S76 neXtProt   PhosphoSitePlus 21204785
Q96FA3 (PELI1) T80 neXtProt   PhosphoSitePlus 21204785
Q96FA3 (PELI1) T288 neXtProt   PhosphoSitePlus 21204785
Q96FA3 (PELI1) S293 neXtProt   PhosphoSitePlus 21204785
Q9BRV8 (SIKE1) S133 PhosphoSitePlus 23649622
Q9BRV8 (SIKE1) S185 PhosphoSitePlus 23649622
Q9BRV8 (SIKE1) S187 PhosphoSitePlus 23649622
Q9BRV8 (SIKE1) S188 PhosphoSitePlus 23649622
Q9BRV8 (SIKE1) S190 PhosphoSitePlus 23649622
Q9BRV8 (SIKE1) S198 PhosphoSitePlus 23649622
Q9UHD2 (TBK1) S172 neXtProt   PhosphoSitePlus   UniProt 21145761, 22619329, 11839743


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028695 (hTBK1/Phos:1) pS172 PRO
PR:000045519 (hTBK1/Phos:2) pS527 PRO 26407194


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96CV9 (OPTN) S177 Q9UHD2 (TBK1) unknown eFIP 25923723


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K65 E65 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R134 C134 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K137 Q137 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S172 Y172 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R228 H228 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K504 E504 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y577 C577 Biomuta DOID:1324 / lung cancer [ cosmic ]
T664 A664 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K691 N691 Biomuta DOID:1319 / brain cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]