iPTMnet Report Q9UHD2 TBK1

Protein Information

UniProt AC / UniProt ID	Q9UHD2 / TBK1_HUMAN
Protein Name	Serine/threonine-protein kinase TBK1
Gene Name	Name: TBK1 Synonyms:NAK;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9UHD2 DAG View
PRO Name	serine/threonine-protein kinase TBK1 (human)
Definition	A serine/threonine-protein kinase TBK1 that is encoded in the genome of human.
Short Label	hTBK1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9UHD2 (TBK1) as Substrate

Q9UHD2

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position K30 R54 K60 K65 K69 R134 K137 S151 Y153 K154 S172 Y174 Y179 R228 K231 K236 K241 S247 K251 T278 K291 Y325 Y340 K344 Y354 K372 Y394 K396 K401 K416 Y435 K484 T503 K504 S509 S511 S527 K545 Y577 K584 K589 Y591 Y592 K596 C605 K607 K608 K615 K646 Y647 Y650 K661 T664 K670 T672 Y677 K691 K692 K702 S716	PTM Type Select all Acetylation Methylation Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 0 1 3 4	Source Select all HPRD IEDB PRO PhosphoSitePlus RLIMS-P Signor UniProt neXtProt phospho.ELM	PMID
K30	Acetylation		score1	PhosphoSitePlus
K30	Ubiquitination		score3	PhosphoSitePlus UniProt	23453971
R54	Methylation		score1	PhosphoSitePlus
K60	Ubiquitination		score1	PhosphoSitePlus
K65	Ubiquitination		score1	PhosphoSitePlus
K69	Ubiquitination		score1	PhosphoSitePlus
R134	Methylation		score1	PhosphoSitePlus
K137	Ubiquitination		score1	PhosphoSitePlus
S151	Phosphorylation		score1	PhosphoSitePlus
Y153	Phosphorylation		score1	PhosphoSitePlus
K154	Acetylation		score1	PhosphoSitePlus
K154	Ubiquitination		score1	PhosphoSitePlus
S172	Phosphorylation	Q9UHD2 (TBK1)	score4	HPRD neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	30853401, 30021902, 11839743, ...18356163, 32772249, 27135603, 29379028, 21931631, 30867315, 32757223, 32514015, 29125880, 25815785, 29755980, 28159912, 25891802, 27538435, 28049762, 26376340, 31442668, 23746807, 30627666, 35406696, 28871090, 22750291, 22619329, 30033073, 25503978, 21145761, 35868534, 27935834, 24752990, 22851595, 19307177, 31379806
Y174	Phosphorylation		score1	PhosphoSitePlus
Y179	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	28049762
R228	Methylation		score1	PhosphoSitePlus
K231	Ubiquitination		score1	PhosphoSitePlus
K236	Acetylation		score1	PhosphoSitePlus
K236	Ubiquitination		score1	PhosphoSitePlus
K241	Acetylation		score1	PhosphoSitePlus
K241	Ubiquitination		score1	PhosphoSitePlus
S247	Phosphorylation		score1	PhosphoSitePlus
K251	Acetylation		score1	PhosphoSitePlus
K251	Ubiquitination		score1	PhosphoSitePlus
T278	Phosphorylation		score1	PhosphoSitePlus
K291	Ubiquitination		score1	PhosphoSitePlus
Y325	Phosphorylation		score1	PhosphoSitePlus
Y340	Phosphorylation		score1	PhosphoSitePlus
K344	Ubiquitination		score1	PhosphoSitePlus
Y354	Phosphorylation		score1	PhosphoSitePlus
K372	Ubiquitination		score1	PhosphoSitePlus
Y394	Phosphorylation		score1	PhosphoSitePlus
K396	Ubiquitination		score1	PhosphoSitePlus
K401	Ubiquitination		score3	PhosphoSitePlus UniProt	23453971
K416	Ubiquitination		score1	PhosphoSitePlus
Y435	Phosphorylation		score1	PhosphoSitePlus
K484	Ubiquitination		score1	PhosphoSitePlus
T503	Phosphorylation		score1	PhosphoSitePlus
K504	Ubiquitination		score1	PhosphoSitePlus
S509	Phosphorylation		score0	HPRD	18691976
S511	Phosphorylation		score1	PhosphoSitePlus
S527	Phosphorylation	Q92630 (DYRK2)	score4	PRO PhosphoSitePlus RLIMS-P	28676338, 26407194
K545	Ubiquitination		score1	PhosphoSitePlus
Y577	Phosphorylation		score1	PhosphoSitePlus
K584	Ubiquitination		score1	PhosphoSitePlus
K589	Ubiquitination		score1	PhosphoSitePlus
Y591	Phosphorylation		score1	PhosphoSitePlus
Y592	Phosphorylation		score1	PhosphoSitePlus
K596	Ubiquitination		score1	PhosphoSitePlus
C605	Methylation		score1	IEDB	33981976, 31844290
K607	Acetylation		score1	PhosphoSitePlus
K608	Ubiquitination		score1	PhosphoSitePlus
K615	Ubiquitination		score1	PhosphoSitePlus
K646	Acetylation		score1	PhosphoSitePlus
K646	Ubiquitination		score1	PhosphoSitePlus
Y647	Phosphorylation		score1	PhosphoSitePlus
Y650	Phosphorylation		score1	PhosphoSitePlus
K661	Ubiquitination		score1	PhosphoSitePlus
T664	Phosphorylation		score1	PhosphoSitePlus
K670	Ubiquitination		score3	UniProt	22388039, 27692986
T672	Phosphorylation		score0	HPRD	18691976
Y677	Phosphorylation		score1	PhosphoSitePlus
K691	Acetylation		score1	PhosphoSitePlus
K692	Acetylation		score1	PhosphoSitePlus
K702	Ubiquitination		score1	PhosphoSitePlus
S716	Phosphorylation	Q04759 (PRKCQ)	score4	HPRD PhosphoSitePlus Signor UniProt	18691976, 31792381, 23186163

Q9UHD2 (TBK1) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all O14920 (IKBKB) P03372 (ESR1) P06213 (INSR) P25963 (NFKBIA) P31749 (AKT1) P42226 (STAT6) P42858 (HTT) Q01094 (E2F1) Q04206 (RELA) Q13501 (SQSTM1) Q13568 (IRF5) Q14653 (IRF3) Q5S007 (LRRK2) Q86WV6 (STING1) Q92985 (IRF7) Q96CV9 (OPTN) Q96FA3 (PELI1) Q9BRV8 (SIKE1) Q9UHD2 (TBK1)	Site Select all By amino acid All Serine All Threonine All Tyrosine By position S13 S36 S76 T80 S133 S158 S172 S173 S175 S177 S181 S185 S187 S188 S190 S198 T288 S293 S305 T308 S332 S358 S385 S386 S396 S398 S402 S403 T404 S405 S407 S471 S472 S473 S477 S479 S513 S536 Y641 S910 S935 S1033	Score Select all 1 2 3 4	Source Select all HPRD PhosphoSitePlus RLIMS-P+ Signor UniProt neXtProt phospho.ELM	PMID
O14920 (IKBKB)	S177	score2	neXtProt	10783893
O14920 (IKBKB)	S181	score2	neXtProt	10783893
P03372 (ESR1)	S305	score2	PhosphoSitePlus	24449872
P06213 (INSR)	S1033	score2	neXtProt	19251743
P25963 (NFKBIA)	S36	score3	HPRD Signor	8601309, 9721103, 11815618, ...10783893
P31749 (AKT1)	T308	score2	PhosphoSitePlus	21329883
P31749 (AKT1)	S473	score4	neXtProt PhosphoSitePlus Signor	21329883, 21106850, 21464307
P42226 (STAT6)	S407	score3	PhosphoSitePlus Signor	22000020
P42226 (STAT6)	Y641	score1	Signor	22000020
P42858 (HTT)	S13	score1	Signor	32757223
Q01094 (E2F1)	S332	score2	PhosphoSitePlus	26724859
Q04206 (RELA)	S536	score3	neXtProt phospho.ELM PhosphoSitePlus Signor	15489227
Q13501 (SQSTM1)	S403	score4	PhosphoSitePlus RLIMS-P+ Signor	22921120, 25972374
Q13568 (IRF5)	S158	score3	PhosphoSitePlus Signor	22412986
Q13568 (IRF5)	S293	score3	PhosphoSitePlus Signor	22412986
Q14653 (IRF3)	S173	score3	neXtProt PhosphoSitePlus	20511230
Q14653 (IRF3)	S175	score3	neXtProt PhosphoSitePlus	20511230
Q14653 (IRF3)	S385	score4	neXtProt phospho.ELM PhosphoSitePlus	17526488, 20511230
Q14653 (IRF3)	S386	score4	neXtProt phospho.ELM PhosphoSitePlus	14703513, 17526488, 20511230
Q14653 (IRF3)	S396	score4	neXtProt PhosphoSitePlus	18272581, 19153595, 17526488, ...20511230, 16914100
Q14653 (IRF3)	S398	score4	neXtProt PhosphoSitePlus	19153595, 17526488, 16914100
Q14653 (IRF3)	S402	score4	neXtProt PhosphoSitePlus	19153595, 17526488, 18272581, ...16914100
Q14653 (IRF3)	T404	score4	neXtProt PhosphoSitePlus	19153595, 17526488
Q14653 (IRF3)	S405	score4	neXtProt PhosphoSitePlus	19153595, 17526488
Q5S007 (LRRK2)	S910	score2	neXtProt	22723946
Q5S007 (LRRK2)	S935	score2	neXtProt	22723946
Q86WV6 (STING1)	S358	score4	neXtProt PhosphoSitePlus Signor	22394562, 18818105
Q92985 (IRF7)	S471	score2	PhosphoSitePlus	16914100
Q92985 (IRF7)	S472	score2	PhosphoSitePlus	16914100
Q92985 (IRF7)	S477	score4	neXtProt PhosphoSitePlus RLIMS-P+	22787218, 16914100
Q92985 (IRF7)	S479	score4	neXtProt PhosphoSitePlus RLIMS-P+	22787218, 16914100
Q96CV9 (OPTN)	S177	score4	neXtProt PhosphoSitePlus	21617041, 26365381, 26376340, ...18307994, 21862579
Q96CV9 (OPTN)	S473	score4	PhosphoSitePlus RLIMS-P+	26365381, 27035970
Q96CV9 (OPTN)	S513	score2	PhosphoSitePlus	26365381
Q96FA3 (PELI1)	S76	score3	neXtProt PhosphoSitePlus	21204785
Q96FA3 (PELI1)	T80	score3	neXtProt PhosphoSitePlus	21204785
Q96FA3 (PELI1)	T288	score3	neXtProt PhosphoSitePlus	21204785
Q96FA3 (PELI1)	S293	score3	neXtProt PhosphoSitePlus	21204785
Q9BRV8 (SIKE1)	S133	score2	PhosphoSitePlus	23649622
Q9BRV8 (SIKE1)	S185	score2	PhosphoSitePlus	23649622
Q9BRV8 (SIKE1)	S187	score2	PhosphoSitePlus	23649622
Q9BRV8 (SIKE1)	S188	score2	PhosphoSitePlus	23649622
Q9BRV8 (SIKE1)	S190	score2	PhosphoSitePlus	23649622
Q9BRV8 (SIKE1)	S198	score2	PhosphoSitePlus	23649622
Q9UHD2 (TBK1)	S172	score4	neXtProt PhosphoSitePlus UniProt	21145761, 22619329, 11839743

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000028695 (hTBK1/Phos:1) PR:000045519 (hTBK1/Phos:2)	Sites Select all pS172 pS527	PTM Enzyme	Source Select all PRO	PMID
	PR:000028695 (hTBK1/Phos:1)	pS172		PRO
	PR:000045519 (hTBK1/Phos:2)	pS527		PRO	26407194

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all Q96CV9 (OPTN)	Site Select all By amino acid All Serine By position S177	Interactant Select all Q9UHD2 (TBK1)	Association type Select all unknown	Source Select all eFIP	PMID
	Phosphorylation	Q96CV9 (OPTN)	S177	Q9UHD2 (TBK1)	unknown	eFIP	25923723

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position K65 R134 K137 S172 R228 K504 Y577 T664 K691	Variant Select all A664 C134 C577 E504 E65 H228 N691 Q137 Y172	Source Select all Biomuta	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K65	E65	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
R134	C134	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K137	Q137	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S172	Y172	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
R228	H228	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K504	E504	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
Y577	C577	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T664	A664	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
K691	N691	Biomuta	DOID:1319 / brain cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q9UHD2 (TBK1)

Protein Information

Interactive Sequence View

Q9UHD2 (TBK1) as Substrate

Q9UHD2 (TBK1) as PTM Enzyme

Proteoforms

PTM-dependent PPI

PTM sites affected in variants