iPTMnet Report for Q9UHC7 (MKRN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UHC7 / MKRN1_HUMAN
Protein Name E3 ubiquitin-protein ligase makorin-1
Gene Name Name: MKRN1
Synonyms:RNF61;
Organism Homo sapiens (Human)

PRO ID PR:Q9UHC7
DAG View
PRO Name E3 ubiquitin-protein ligase makorin-1 (human)
Definition A makorin-1 that is encoded in the genome of human.
Short Label hMKRN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UHC7 (MKRN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K70 Ubiquitination PhosphoSitePlus
R95 Methylation PhosphoSitePlus
S109 Phosphorylation RLIMS-P 26183061
K113 Ubiquitination PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
Y309 Phosphorylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K360 Acetylation PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
Y411 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S109 C109 Biomuta DOID:1324 / lung cancer [ cosmic ]
T123 A123 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S194 L194 Biomuta DOID:1324 / lung cancer [ cosmic ]
K326 * Biomuta DOID:4159 / skin cancer [ cosmic ]