iPTMnet Report for Q9UHC1 (MLH3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UHC1 / MLH3_HUMAN
Protein Name DNA mismatch repair protein Mlh3
Gene Name Name: MLH3
Organism Homo sapiens (Human)

PRO ID PR:Q9UHC1
DAG View
PRO Name DNA mismatch repair protein Mlh3 (human)
Definition A DNA mismatch repair protein Mlh3 that is encoded in the genome of human.
Short Label hMLH3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UHC1 (MLH3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K128 Ubiquitination PhosphoSitePlus
T147 Phosphorylation IEDB 32357974
S188 Phosphorylation PhosphoSitePlus
T335 Phosphorylation IEDB 35494241
K380 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
T422 Phosphorylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
R600 Methylation PhosphoSitePlus
T606 Phosphorylation PhosphoSitePlus
T610 Phosphorylation PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
K628 Ubiquitination PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
K664 Ubiquitination PhosphoSitePlus
Y681 Phosphorylation PhosphoSitePlus
T690 Phosphorylation PhosphoSitePlus
Y691 Phosphorylation PhosphoSitePlus
S746 Phosphorylation PhosphoSitePlus
S753 Phosphorylation PhosphoSitePlus
K876 Ubiquitination PhosphoSitePlus
K881 Acetylation PhosphoSitePlus
S883 Phosphorylation PhosphoSitePlus
K982 Ubiquitination PhosphoSitePlus
T1062 Phosphorylation PhosphoSitePlus
T1128 Phosphorylation PhosphoSitePlus
S1188 Phosphorylation PhosphoSitePlus
T1208 Phosphorylation PhosphoSitePlus
K1243 Ubiquitination PhosphoSitePlus
S1256 Phosphorylation PhosphoSitePlus
S1257 Phosphorylation PhosphoSitePlus
T1258 Phosphorylation PhosphoSitePlus
K1413 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T147 K147 Biomuta DOID:3571 / liver cancer [ cosmic ]
S188 Y188 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R600 Q600 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T610 I610 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K628 T628 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y681 H681 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S746 R746 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S753 Y753 Biomuta DOID:363 / uterine cancer [ icgc ]
K876 R876 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K881 T881 Biomuta DOID:363 / uterine cancer [ cosmic ]
S883 F883 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]