iPTMnet Report for Q9UHB7 (AFF4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UHB7 / AFF4_HUMAN
Protein Name AF4/FMR2 family member 4
Gene Name Name: AFF4
Synonyms:AF5Q31,MCEF;ORFNames:HSPC092;
Organism Homo sapiens (Human)

PRO ID PR:Q9UHB7
DAG View
PRO Name AF4/FMR2 family member 4 (human)
Definition An AF4/FMR2 family member 4 that is encoded in the genome of human.
Short Label hAFF4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UHB7 (AFF4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
Y39 Phosphorylation PhosphoSitePlus
T42 O-Glycosylation GlyGen 29485866, 30379171, 30620550, ...30059200, 31637018
S43 O-Glycosylation GlyGen 29485866, 30379171, 30620550, ...30059200, 31637018
S49 Phosphorylation PhosphoSitePlus
K79 Acetylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
T117 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus   UniProt 23186163
S124 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
K166 Acetylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S180 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S188 Phosphorylation PhosphoSitePlus
S193 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S195 Phosphorylation phospho.ELM 18669648
S210 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S212 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
S222 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
S229 O-Glycosylation GlyGen 29485866, 30379171, 30620550, ...30059200, 31637018
K252 Acetylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
T332 Phosphorylation PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
T359 Phosphorylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
S387 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S388 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S389 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S392 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S440 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S490 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
S499 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
Y502 Phosphorylation PhosphoSitePlus
K504 Acetylation PhosphoSitePlus
T511 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
T516 Phosphorylation PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
T528 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus
S549 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17081983, 19369195
S553 Phosphorylation PhosphoSitePlus
K583 Sumoylation PhosphoSitePlus
S586 O-Glycosylation GlyGen 30379171
T588 Phosphorylation PhosphoSitePlus
S599 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S619 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
Y668 Phosphorylation PhosphoSitePlus
S671 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648
T674 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
K677 Ubiquitination PhosphoSitePlus
S679 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S680 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S686 Phosphorylation PhosphoSitePlus
S694 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S703 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S706 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...24275569
Y712 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K747 Acetylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
S800 Phosphorylation PhosphoSitePlus
S801 Phosphorylation PhosphoSitePlus
S804 Phosphorylation PhosphoSitePlus
S814 O-Glycosylation GlyGen 29485866, 30379171, 30620550, ...30059200, 31637018
S814 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 20068231
S821 Phosphorylation PhosphoSitePlus
K822 Acetylation PhosphoSitePlus
T834 Phosphorylation PhosphoSitePlus
S836 Phosphorylation IEDB   PhosphoSitePlus   UniProt 23186163, 32387766, 31848261, ...20068231
S839 Phosphorylation PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
S845 Phosphorylation PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus
K849 Acetylation PhosphoSitePlus
T851 O-Glycosylation GlyGen 29485866, 30379171, 30620550, ...30059200, 31637018
S854 O-Glycosylation GlyGen 29485866, 30379171, 30620550, ...30059200, 31637018
S855 O-Glycosylation GlyGen 29485866, 30379171, 30620550, ...30059200, 31637018
T867 Phosphorylation PhosphoSitePlus
T871 O-Glycosylation GlyGen 29485866, 30379171, 30620550, ...30059200, 31637018
T871 Phosphorylation PhosphoSitePlus
S872 Phosphorylation PhosphoSitePlus
S873 Phosphorylation PhosphoSitePlus
S874 Phosphorylation PhosphoSitePlus
S875 Phosphorylation PhosphoSitePlus
K905 Ubiquitination PhosphoSitePlus
R911 Methylation PhosphoSitePlus
R935 Methylation PhosphoSitePlus
S963 Phosphorylation PhosphoSitePlus
S965 Phosphorylation PhosphoSitePlus
T973 Phosphorylation PhosphoSitePlus
Y986 Phosphorylation PhosphoSitePlus
T999 Phosphorylation PhosphoSitePlus
K1026 Ubiquitination PhosphoSitePlus
S1039 Phosphorylation PhosphoSitePlus
S1043 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 23186163, 18691976, ...15302935, 18669648, 20068231
S1048 Phosphorylation PhosphoSitePlus
S1055 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648
S1058 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 23186163, 15302935, ...18669648, 19690332, 27869121
S1062 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935
S1066 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
Y1069 Phosphorylation PhosphoSitePlus
K1121 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation HPRD 18691976
S32 Phosphorylation HPRD 18691976
S124 Phosphorylation HPRD 18691976
S176 Phosphorylation HPRD 18691976
S178 Phosphorylation HPRD 18691976, 18452278
S179 Phosphorylation HPRD 18691976, 17081983, 18452278
S180 Phosphorylation HPRD 18669648, 18452278, 17081983, ...20068230
S193 Phosphorylation HPRD 18669648
S195 Phosphorylation HPRD 18669648
S210 Phosphorylation HPRD 19651622, 18691976
S212 Phosphorylation HPRD 17322306, 18691976, 19651622
S222 Phosphorylation HPRD 18691976
S387 Phosphorylation HPRD 19651622, 18669648, 17081983
S388 Phosphorylation HPRD 19651622, 18669648, 17081983
S389 Phosphorylation HPRD 19651622, 18669648, 17081983
S392 Phosphorylation HPRD 19651622, 18669648, 17081983
S487 Phosphorylation HPRD 19413330, 18691976, 18077418, ...19691289, 18452278, 19651622
S490 Phosphorylation HPRD 19651622, 18691976, 18077418, ...17081983
S491 Phosphorylation HPRD 19413330, 19651622, 18077418
S494 Phosphorylation HPRD 17081983
S499 Phosphorylation HPRD 17525332, 18077418
Y502 Phosphorylation HPRD 18691976
S514 Phosphorylation HPRD 18691976
T528 Phosphorylation HPRD 18691976
S549 Phosphorylation HPRD 19651622, 18691976, 17081983, ...20068231
S598 Phosphorylation HPRD 20068231
S599 Phosphorylation HPRD 18691976, 18669648, 17081983
S671 Phosphorylation HPRD 18669648
T674 Phosphorylation HPRD 18691976, 18452278
S679 Phosphorylation HPRD 18691976, 18669648
S680 Phosphorylation HPRD 18691976, 18669648
S694 Phosphorylation HPRD 18691976, 18669648, 20068231
S703 Phosphorylation HPRD 19413330, 18691976, 17081983, ...19651622, 18669648, 20068231
S706 Phosphorylation HPRD 19413330, 18691976, 17081983, ...18452278, 19651622, 18669648, 20068231
Y712 Phosphorylation HPRD 18669648
S814 Phosphorylation HPRD 19651622, 18691976, 20068231
S836 Phosphorylation HPRD 18691976, 18077418, 19664995, ...20068231
S839 Phosphorylation HPRD 20068231
S1039 Phosphorylation HPRD 19664995, 20068231
S1043 Phosphorylation HPRD 19413330, 18691976, 19664994, ...19664995, 19691289, 18669648, 20068231
S1055 Phosphorylation HPRD 19413330, 18691976, 18669648, ...19651622, 20068231
S1058 Phosphorylation HPRD 19413330, 18691976, 18669648, ...19651622, 20068231
S1062 Phosphorylation HPRD 19413330, 18691976, 18669648, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T42 S42 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S178 C178 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S178 F178 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S179 F179 Biomuta DOID:4159 / skin cancer [ cosmic ]
K292 T292 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S314 R314 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K344 T344 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S514 I514 Biomuta DOID:363 / uterine cancer [ icgc ]
S519 G519 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S526 F526 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
S549 F549 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T588 N588 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S680 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S686 T686 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K747 T747 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K822 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S839 F839 Biomuta DOID:1319 / brain cancer [ cosmic ]
S840 A840 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S840 F840 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T851 M851 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic ]
S875 F875 Biomuta DOID:4159 / skin cancer [ cosmic ]
S965 C965 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S965 F965 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y986 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S1039 Y1039 Biomuta DOID:363 / uterine cancer [ icgc ]
S1048 I1048 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1062 * Biomuta DOID:363 / uterine cancer [ cosmic ]