iPTMnet Report for Q9UHB6 (LIMA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UHB6 / LIMA1_HUMAN
Protein Name LIM domain and actin-binding protein 1
Gene Name Name: LIMA1
Synonyms:EPLIN;ORFNames:PP624;
Organism Homo sapiens (Human)

PRO ID PR:Q9UHB6
DAG View
PRO Name LIM domain and actin-binding protein 1 (human)
Definition A LIM domain and actin-binding protein 1 that is encoded in the genome of human.
Short Label hLIMA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UHB6 (LIMA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 20068231
S4 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
T12 Phosphorylation PhosphoSitePlus
S15 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K21 Ubiquitination PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
Y41 Phosphorylation IEDB   PhosphoSitePlus 32387766
K43 Ubiquitination PhosphoSitePlus
S55 O-Glycosylation GlyGen 23301498, 33214551, 34019948, ...33465208, 35254053
S55 Phosphorylation PhosphoSitePlus   UniProt 23186163
T57 O-Glycosylation GlyGen 23301498, 33214551, 34019948, ...33465208, 35254053
T57 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
S132 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...20068231, 17924679
Y142 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
K159 Acetylation PhosphoSitePlus
K160 Acetylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
T181 O-Glycosylation GlyGen 33465208
A183 Phosphorylation UniProt 20068231
S184 O-Glycosylation GlyGen 23301498, 33214551, 34019948, ...33465208, 35254053
S184 Phosphorylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
K198 Methylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
S225 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
S228 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y229 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S230 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S242 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
T265 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K273 Acetylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus
S279 O-Glycosylation GlyGen 23301498, 33214551, 35254053, ...34019948, 33465208, 29237092
S279 Phosphorylation PhosphoSitePlus
K280 Methylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
T285 O-Glycosylation GlyGen 23301498, 33214551, 34019948, ...33465208, 35254053
Y287 Phosphorylation PhosphoSitePlus
T288 O-Glycosylation GlyGen 33465208
T288 Phosphorylation PhosphoSitePlus
K292 Methylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
T337 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus   UniProt 20068231
S346 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus   UniProt 21406692
K359 Ubiquitination PhosphoSitePlus
S362 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 21406692, 23186163, 17081983, ...23188829, 18669648, 24275569, 17287340, 20068231, 17924679
S362 Phosphorylation P27361 (MAPK3) RLIMS-P+ 23188829
S362 Phosphorylation P28482 (MAPK1) RLIMS-P+   Signor 23188829
S365 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 24275569
S368 O-Glycosylation GlyGen 23301498, 33214551, 34019948, ...33465208, 35254053
S368 Phosphorylation PhosphoSitePlus
S369 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S371 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
S374 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 27920218, 18669648, 24275569, 20068231
C414 Methylation IEDB 31844290
T428 Phosphorylation PhosphoSitePlus
Y429 Phosphorylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
Y437 Phosphorylation PhosphoSitePlus
C438 Methylation IEDB 31844290
K447 Methylation PhosphoSitePlus
K449 Methylation PhosphoSitePlus
Y452 Phosphorylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
T487 Phosphorylation phospho.ELM   PhosphoSitePlus 16083285
S490 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 16083285, ...18088087, 17081983, 18669648, 17287340, 24275569, 23186163, 20068231, 17924679
S507 Phosphorylation PhosphoSitePlus
T536 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
S582 Phosphorylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
T592 Phosphorylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
S599 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T600 Phosphorylation PhosphoSitePlus
S601 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S604 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 23186163, 23188829, 16565220, ...18669648, 19690332, 20068231
S604 Phosphorylation P27361 (MAPK3) RLIMS-P+ 23188829
S604 Phosphorylation P28482 (MAPK1) RLIMS-P+   Signor 23188829
T607 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S609 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S617 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S619 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S622 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S625 Phosphorylation PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
S666 Phosphorylation PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
S686 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 18669648, 19690332, 20068231
S692 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 17081983, ...20068231
S698 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983
S704 Phosphorylation PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus
S709 Phosphorylation PhosphoSitePlus
T714 Phosphorylation PhosphoSitePlus
S726 Phosphorylation PhosphoSitePlus   UniProt 21406692
S741 Phosphorylation PhosphoSitePlus
K747 Ubiquitination PhosphoSitePlus
Y751 Phosphorylation PhosphoSitePlus
Y752 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD 19691289, 20068231
S15 Phosphorylation HPRD 18669648, 20068231
S132 Phosphorylation HPRD 18691976, 19691289, 19007248, ...18669648, 20068231, 17924679
S225 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231, 18452278
S228 Phosphorylation HPRD 18669648, 20068231, 18452278
Y229 Phosphorylation HPRD 18669648, 20068231
S230 Phosphorylation HPRD 18669648
S263 Phosphorylation HPRD 19007248, 20068231, 19691289
S266 Phosphorylation HPRD 20068231
S279 Phosphorylation HPRD 20068231
S331 Phosphorylation HPRD 19691289
S336 Phosphorylation HPRD 20068231
T337 Phosphorylation HPRD 20068231
S343 Phosphorylation HPRD 20068231
S362 Phosphorylation HPRD 18691976, 18491316, 17287340, ...17081983, 19691289, 19664995, 19651622, 18669648, 18707149, 20068231, 17924679
S365 Phosphorylation HPRD 18669648, 17081983, 20068231, ...17924679
S368 Phosphorylation HPRD 19413330
S369 Phosphorylation HPRD 18669648, 19664995, 20068231
S371 Phosphorylation HPRD 19413330
S373 Phosphorylation HPRD 17322306, 18691976, 19415658, ...20068231, 19664995
S374 Phosphorylation HPRD 19413330, 18691976, 19562805, ...15302935, 19691289, 19664995, 19651622, 18669648, 19007248, 16565220, 19415658, 20068231, 17924679
T487 Phosphorylation HPRD 19651622, 18767875, 20068231, ...17924679
S490 Phosphorylation HPRD 18691976, 18578522, 16083285, ...18088087, 18767875, 19664995, 19007248, 19651622, 18669648, 18707149, 17287340, 16565220, 17924679, 19415658, 20068231, 19691289
S540 Phosphorylation HPRD 20068231
S588 Phosphorylation HPRD 19415658
T592 Phosphorylation HPRD 19415658
S599 Phosphorylation HPRD 18669648
S601 Phosphorylation HPRD 18669648
S604 Phosphorylation HPRD 18669648, 19691289, 20068231, ...16565220
T607 Phosphorylation HPRD 18669648
S609 Phosphorylation HPRD 19413330, 19691289, 18767875, ...19007248, 19664995, 17322306, 18669648, 20068231, 20068230
S617 Phosphorylation HPRD 18669648, 20068231
S619 Phosphorylation HPRD 18669648, 20068231
S622 Phosphorylation HPRD 18669648, 20068231
S625 Phosphorylation HPRD 20068231
S686 Phosphorylation HPRD 18691976, 18491316, 17081983, ...18452278, 18669648, 20166139, 20068231
S692 Phosphorylation HPRD 18691976, 18669648, 17081983, ...20068231, 18452278
S698 Phosphorylation HPRD 18669648, 17081983, 20068231
S709 Phosphorylation HPRD 20068231
S726 Phosphorylation HPRD 18077418, 19691289
S741 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S331 Phosphorylation PhosphoSitePlus
T337 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S32 L32 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
T57 I57 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S61 Y61 Biomuta DOID:3571 / liver cancer [ cosmic ]
K75 N75 Biomuta DOID:1319 / brain cancer [ cosmic ]
S132 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S168 F168 Biomuta DOID:4159 / skin cancer [ cosmic ]
T181 A181 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y190 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
S263 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S266 F266 Biomuta DOID:4159 / skin cancer [ cosmic ]
S266 P266 Biomuta DOID:4159 / skin cancer [ cosmic ]
S326 F326 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
S346 P346 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S365 F365 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ]
S366 F366 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ]
S369 G369 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S373 N373 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S507 I507 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S601 Y601 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S601 F601 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S617 N617 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S625 F625 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K650 N650 Biomuta DOID:3571 / liver cancer [ cosmic ]
S709 C709 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K747 Q747 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]