iPTMnet Report for Q9UH77 (KLHL3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UH77 / KLHL3_HUMAN
Protein Name Kelch-like protein 3
Gene Name Name: KLHL3
Synonyms:KIAA1129;
Organism Homo sapiens (Human)

PRO ID PR:Q9UH77
DAG View
PRO Name kelch-like protein 3 (human)
Definition A kelch-like protein 3 that is encoded in the genome of human.
Short Label hKLHL3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UH77 (KLHL3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
S10 Phosphorylation UniProt 26435498
T12 Phosphorylation PhosphoSitePlus
T100 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
T295 Phosphorylation UniProt 26435498
T375 Phosphorylation UniProt 26435498
S376 Phosphorylation UniProt 26435498
S433 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   RLIMS-P   UniProt 27727489, 26435498, 30718414, ...25313067
K518 Methylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
Y577 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9UH77 (KLHL3) S433 Q96J92 (WNK4) inhibited_association eFIP 27727489


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 T9 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S10 F10 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S208 Y208 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S209 L209 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
T375 M375 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
K518 N518 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]