iPTMnet Report for Q9UGU5 (HMGXB4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UGU5 / HMGX4_HUMAN
Protein Name HMG domain-containing protein 4
Gene Name Name: HMGXB4
Synonyms:HMG2L1,HMGBCG;
Organism Homo sapiens (Human)

PRO ID PR:Q9UGU5
DAG View
PRO Name HMG domain-containing protein 4 (human)
Definition An HMG domain-containing protein 4 that is encoded in the genome of human.
Short Label hHMGXB4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UGU5 (HMGXB4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Sumoylation PhosphoSitePlus
S79 Phosphorylation HPRD   PhosphoSitePlus 18452278
S80 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
Y85 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
S101 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18452278
S102 Phosphorylation PhosphoSitePlus   UniProt 23186163
T106 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus   UniProt 21406692
S223 Phosphorylation PhosphoSitePlus
T247 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
S345 Phosphorylation HPRD   PhosphoSitePlus 20068231
S387 Phosphorylation HPRD 20068231
K459 Ubiquitination PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
S485 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S502 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 18452278, ...19651622, 20068231
S512 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 18452278, ...19651622, 20068231
T519 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S89 L89 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc, tcga ] DOID:9256 / colorectal cancer [ cosmic ]
S118 P118 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S166 C166 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S223 F223 Biomuta DOID:4159 / skin cancer [ cosmic ]
S480 Y480 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
S481 I481 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S502 Y502 Biomuta DOID:4159 / skin cancer [ cosmic ]
S502 F502 Biomuta DOID:4159 / skin cancer [ cosmic ]