Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9UGP5 / DPOLL_HUMAN
Protein Name DNA polymerase lambda
Gene Name Name: POLL
Organism Homo sapiens (Human)

DAG View
PRO Name DNA polymerase lambda (human)
Definition A DNA polymerase lambda that is encoded in the genome of human.
Short Label hPOLL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9UGP5 (POLL) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K23 Ubiquitination PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
S167 Phosphorylation P24941 (CDK2) neXtProt   PhosphoSitePlus 18688254
T173 Phosphorylation PhosphoSitePlus
S177 Phosphorylation P24941 (CDK2) neXtProt   PhosphoSitePlus 18688254
T204 Phosphorylation PhosphoSitePlus
S230 Phosphorylation P24941 (CDK2) neXtProt   PhosphoSitePlus 18688254
S246 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K248 Ubiquitination PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
Y380 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
K544 Acetylation PhosphoSitePlus
T553 Phosphorylation P24941 (CDK2) neXtProt   PhosphoSitePlus 18688254
Site PTM Type PTM Enzyme Score Source PMID
S246 Phosphorylation HPRD 17525332

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T173 P173 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S230 T230 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]