iPTMnet Report for Q9UGN5 (PARP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UGN5 / PARP2_HUMAN
Protein Name Poly [ADP-ribose] polymerase 2
Gene Name Name: PARP2
Synonyms:ADPRT2,ADPRTL2;
Organism Homo sapiens (Human)

PRO ID PR:Q9UGN5
DAG View
PRO Name poly [ADP-ribose] polymerase 2 (human)
Definition A poly [ADP-ribose] polymerase 2 that is encoded in the genome of human.
Short Label hPARP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UGN5 (PARP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
T9 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus   UniProt 21406692
K229 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus   UniProt 21406692
K269 Ubiquitination PhosphoSitePlus
T271 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
T389 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S33 Phosphorylation HPRD 19651622, 20068231
S34 Phosphorylation HPRD 19651622, 19664995
Site PTM Type PTM Enzyme Score Source PMID
S33 Phosphorylation HPRD 19651622, 20068231
S34 Phosphorylation HPRD 19651622, 19664995
K71 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 C8 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S33 C33 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S34 F34 Biomuta DOID:4159 / skin cancer [ cosmic ]
S34 T34 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S47 L47 Biomuta DOID:1612 / breast cancer [ cosmic ]
S226 C226 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S226 F226 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T317 N317 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S353 N353 Biomuta DOID:363 / uterine cancer [ icgc ]
T389 A389 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K480 N480 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K512 N512 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]