Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UGL1 / KDM5B_HUMAN
Protein Name Lysine-specific demethylase 5B
Gene Name Name: KDM5B
Synonyms:JARID1B,PLU1,RBBP2H1;
Organism Homo sapiens (Human)

PRO ID PR:Q9UGL1
DAG View
PRO Name lysine-specific demethylase 5B (human)
Definition A lysine-specific demethylase 5B that is encoded in the genome of human.
Short Label hKDM5B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UGL1 (KDM5B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K63 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
T84 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
Y110 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K196 Acetylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K209 Sumoylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K242 Sumoylation PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
T264 Phosphorylation PhosphoSitePlus
K278 Sumoylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
T476 Phosphorylation PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
K729 Ubiquitination PhosphoSitePlus
Y730 Phosphorylation PhosphoSitePlus
Y734 Phosphorylation PhosphoSitePlus
Y736 Phosphorylation PhosphoSitePlus
Y742 Phosphorylation PhosphoSitePlus
K749 Ubiquitination PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus
K774 Ubiquitination PhosphoSitePlus
K780 Ubiquitination PhosphoSitePlus
K789 Ubiquitination PhosphoSitePlus
K790 Ubiquitination PhosphoSitePlus
K809 Ubiquitination PhosphoSitePlus
S812 Phosphorylation PhosphoSitePlus
K821 Ubiquitination PhosphoSitePlus
K832 Acetylation PhosphoSitePlus
K832 Ubiquitination PhosphoSitePlus
K956 Ubiquitination PhosphoSitePlus
K974 Ubiquitination PhosphoSitePlus
K976 Ubiquitination PhosphoSitePlus
K980 Ubiquitination PhosphoSitePlus
S986 Phosphorylation PhosphoSitePlus   UniProt 23186163
K995 Ubiquitination PhosphoSitePlus
K1011 Ubiquitination PhosphoSitePlus
S1055 Phosphorylation PhosphoSitePlus
K1102 Ubiquitination PhosphoSitePlus
K1107 Acetylation PhosphoSitePlus
K1121 Sumoylation PhosphoSitePlus
K1121 Ubiquitination PhosphoSitePlus
S1126 Phosphorylation PhosphoSitePlus
S1135 Phosphorylation PhosphoSitePlus
K1136 Ubiquitination PhosphoSitePlus
T1144 Phosphorylation PhosphoSitePlus
S1158 Phosphorylation PhosphoSitePlus
K1166 Ubiquitination PhosphoSitePlus
S1169 Phosphorylation PhosphoSitePlus
K1183 Ubiquitination PhosphoSitePlus
K1226 Ubiquitination PhosphoSitePlus
S1238 Phosphorylation PhosphoSitePlus
K1276 Ubiquitination PhosphoSitePlus
S1328 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1383 Phosphorylation PhosphoSitePlus
S1384 Phosphorylation PhosphoSitePlus
K1392 Ubiquitination PhosphoSitePlus
S1405 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1420 Phosphorylation PhosphoSitePlus
K1444 Ubiquitination PhosphoSitePlus
K1450 Sumoylation PhosphoSitePlus
K1450 Ubiquitination PhosphoSitePlus
S1456 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S986 Phosphorylation HPRD 20068231
S1383 Phosphorylation HPRD 17081983
S1384 Phosphorylation HPRD 17081983
S1405 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K63 N63 Biomuta DOID:1324 / lung cancer [ tcga ]
T84 M84 Biomuta DOID:1324 / lung cancer [ cosmic ]
K109 N109 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K126 N126 Biomuta DOID:1612 / breast cancer [ tcga ]
K278 Q278 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K390 T390 Biomuta DOID:363 / uterine cancer [ tcga ]
S457 N457 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1612 / breast cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
T476 N476 Biomuta DOID:3571 / liver cancer [ icgc ]
K635 M635 Biomuta DOID:1324 / lung cancer [ tcga ]
K729 E729 Biomuta DOID:0070003 / blastoma [ cosmic ]
Y736 C736 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K749 N749 Biomuta DOID:3953 / adrenal gland cancer [ tcga ]
K790 T790 Biomuta DOID:363 / uterine cancer [ tcga ]
S812 F812 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K976 N976 Biomuta DOID:363 / uterine cancer [ tcga ]
S986 T986 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]
S986 * Biomuta DOID:3571 / liver cancer [ icgc ]
S1055 Y1055 Biomuta DOID:363 / uterine cancer [ tcga ]
K1121 E1121 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S1126 G1126 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T1144 A1144 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1158 Y1158 Biomuta DOID:363 / uterine cancer [ tcga ]
K1166 Q1166 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S1328 P1328 Biomuta DOID:9256 / colorectal cancer [ tcga ]