iPTMnet Report for Q9UGK3 (STAP2)
Protein Information
| UniProt AC / UniProt ID | Q9UGK3 / STAP2_HUMAN |
| Protein Name | Signal-transducing adaptor protein 2 |
| Gene Name | Name: STAP2 Synonyms:BKS; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9UGK3 |
| PRO Name | signal-transducing adaptor protein 2 (human) |
| Definition | A signal-transducing adaptor protein 2 that is encoded in the genome of human. |
| Short Label | hSTAP2 |
| Category | organism-gene |
DAG ViewQ9UGK3 (STAP2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y22 | Phosphorylation | score3 | neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 12540842 | ||
| Y22 | Phosphorylation | O60674 (JAK2) | score3 | neXtProt PhosphoSitePlus | 12540842 | |
| Y22 | Phosphorylation | P12931 (SRC) | score3 | PhosphoSitePlus Signor | 12540842 | |
| C172 | Methylation | score1 | IEDB | 31844290 | ||
| T191 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y204 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y250 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 12540842, 19393627, 28478037, ... | ||
| Y250 | Phosphorylation | O60674 (JAK2) | score2 | PhosphoSitePlus | 12540842 | |
| Y250 | Phosphorylation | P12931 (SRC) | score2 | PhosphoSitePlus | 12540842 | |
| Y250 | Phosphorylation | Q13882 (PTK6) | score3 | neXtProt PhosphoSitePlus Signor | 19393627 | |
| Y256 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T282 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S289 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y310 | Phosphorylation | score3 | neXtProt phospho.ELM PhosphoSitePlus UniProt | 12540842 | ||
| Y310 | Phosphorylation | O60674 (JAK2) | score3 | neXtProt PhosphoSitePlus | 12540842 | |
| Y322 | Phosphorylation | score3 | neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 12540842 | ||
| Y322 | Phosphorylation | O60674 (JAK2) | score3 | neXtProt PhosphoSitePlus | 12540842 | |
| Y322 | Phosphorylation | P12931 (SRC) | score3 | PhosphoSitePlus Signor | 12540842 | |
| K337 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T381 | O-Glycosylation | score1 | GlyGen | 32574038 | ||
| T388 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y22 | Phosphorylation | score1 | HPRD | 12540842 | ||
| Y22 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 12540842 | |
| Y250 | Phosphorylation | score1 | HPRD | 12540842 | ||
| Y250 | Phosphorylation | O60674 (JAK2) | score1 | HPRD | 12540842 | |
| Y250 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 12540842 | |
| Y310 | Phosphorylation | score1 | HPRD | 12540842 | ||
| Y310 | Phosphorylation | O60674 (JAK2) | score1 | HPRD | 12540842 | |
| Y310 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 12540842 | |
| Y322 | Phosphorylation | score1 | HPRD | 12540842 | ||
| Y322 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 12540842 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y22 | Phosphorylation | score1 | HPRD | 12540842 | ||
| Y22 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 12540842 | |
| Y250 | Phosphorylation | score1 | HPRD | 12540842 | ||
| Y250 | Phosphorylation | O60674 (JAK2) | score1 | HPRD | 12540842 | |
| Y250 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 12540842 | |
| Y310 | Phosphorylation | score1 | HPRD | 12540842 | ||
| Y310 | Phosphorylation | O60674 (JAK2) | score1 | HPRD | 12540842 | |
| Y310 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 12540842 | |
| Y322 | Phosphorylation | score1 | HPRD | 12540842 | ||
| Y322 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 12540842 |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q9UGK3 (STAP2) | Y250 | Q14289 (PTK2B) | unknown | eFIP | 28478037 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T191 | M191 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| T388 | M388 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] |
