iPTMnet Report for Q9UEY8 (ADD3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UEY8 / ADDG_HUMAN
Protein Name Gamma-adducin
Gene Name Name: ADD3
Synonyms:ADDL;
Organism Homo sapiens (Human)

PRO ID PR:Q9UEY8
DAG View
PRO Name gamma-adducin (human)
Definition A gamma-adducin that is encoded in the genome of human.
Short Label hADD3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UEY8 (ADD3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 20068231
T12 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
R27 Methylation PhosphoSitePlus
Y35 Phosphorylation PhosphoSitePlus
S42 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 18088087, ...20068231
T59 Phosphorylation PhosphoSitePlus
S64 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
T159 O-Glycosylation GlyGen 30379171, 29351928
S162 O-Glycosylation GlyGen 30379171, 29351928
K280 Ubiquitination PhosphoSitePlus
C317 Methylation IEDB 31844290
K340 Methylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
Y383 Phosphorylation PhosphoSitePlus
Y389 Phosphorylation PhosphoSitePlus
R390 Methylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus   UniProt 19690332
T409 Phosphorylation PhosphoSitePlus
T411 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
T419 Phosphorylation PhosphoSitePlus
S423 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 18847512
K426 Ubiquitination PhosphoSitePlus
Y427 Phosphorylation PhosphoSitePlus
K436 Acetylation PhosphoSitePlus
S442 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T445 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
T460 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus   UniProt 23186163
T464 O-Glycosylation GlyGen 30379171, 29351928
T464 Phosphorylation PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
T481 Phosphorylation PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
Y565 Phosphorylation PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
S647 Phosphorylation PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus
T651 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus
T654 Phosphorylation PhosphoSitePlus
S673 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...20068231
S677 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
S679 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935
S681 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18088087, 17081983, ...15302935, 18669648, 23186163, 19690332
S683 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
T691 Phosphorylation PhosphoSitePlus
S693 Phosphorylation O14757 (CHEK1) phospho.ELM   PhosphoSitePlus 18669648, 21851590, 11895774
Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 20068231
T12 Phosphorylation HPRD 19413330
S42 Phosphorylation HPRD 18088087, 18669648, 19664994, ...19664995, 20068231
S64 Phosphorylation HPRD 18669648, 19664994
S180 Phosphorylation HPRD 20068231
S187 Phosphorylation HPRD 20068231
Y383 Phosphorylation HPRD 20068231
S402 Phosphorylation HPRD 20068231
S423 Phosphorylation HPRD 18669648, 20068231
S442 Phosphorylation HPRD 18669648
S461 Phosphorylation HPRD 20166139
S478 Phosphorylation HPRD 20068231
S650 Phosphorylation HPRD 20068231
S673 Phosphorylation HPRD 17081983, 18767875, 19664994, ...18452278, 19651622, 18669648, 20068231
S677 Phosphorylation HPRD 17081983, 18767875, 19664994, ...18452278, 19651622, 18669648, 20068231
S679 Phosphorylation HPRD 19651622, 20166139, 18669648, ...17081983, 20068231
S681 Phosphorylation HPRD 18088087, 17081983, 18767875, ...19664994, 18452278, 19651622, 18669648, 20166139, 20068231
S683 Phosphorylation HPRD 20166139, 18767875, 20068231, ...18452278
T691 Phosphorylation HPRD 20068231, 18452278
S693 Phosphorylation P17252 (PRKCA) HPRD 11895774, 18452278, 19651622, ...18669648, 20166139, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 20068231
T12 Phosphorylation HPRD 19413330
S42 Phosphorylation HPRD 18088087, 18669648, 19664994, ...19664995, 20068231
S64 Phosphorylation HPRD 18669648, 19664994
S180 Phosphorylation HPRD 20068231
S187 Phosphorylation HPRD 20068231
Y383 Phosphorylation HPRD 20068231
S402 Phosphorylation HPRD 20068231
S423 Phosphorylation HPRD 18669648, 20068231
S442 Phosphorylation HPRD 18669648
S461 Phosphorylation HPRD 20166139
S478 Phosphorylation HPRD 20068231
S618 Phosphorylation HPRD 20068231
S641 Phosphorylation HPRD 17081983, 18767875, 19664994, ...18452278, 19651622, 18669648, 20068231
S645 Phosphorylation HPRD 17081983, 18767875, 19664994, ...18452278, 19651622, 18669648, 20068231
S647 Phosphorylation HPRD 19651622, 20166139, 18669648, ...17081983, 20068231
S649 Phosphorylation HPRD 18088087, 17081983, 18767875, ...19664994, 18452278, 19651622, 18669648, 20166139, 20068231
S651 Phosphorylation HPRD 20166139, 18767875, 20068231, ...18452278
T659 Phosphorylation HPRD 20068231, 18452278
S661 Phosphorylation P17252 (PRKCA) HPRD 11895774, 18452278, 19651622, ...18669648, 20166139, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T11 S11 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S17 R17 Biomuta DOID:1324 / lung cancer [ cosmic ]
C317 F317 Biomuta DOID:1324 / lung cancer [ cosmic ]
S360 F360 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S402 G402 Biomuta DOID:4159 / skin cancer [ cosmic ]
S414 F414 Biomuta DOID:4159 / skin cancer [ cosmic ]
S455 Y455 Biomuta DOID:1319 / brain cancer [ icgc ]
S461 G461 Biomuta DOID:1324 / lung cancer [ cosmic ]
T467 M467 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S649 L649 Biomuta DOID:4159 / skin cancer [ cosmic ]
S681 L681 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]