iPTMnet Report Q9UEW8 STK39

Protein Information

UniProt AC / UniProt ID	Q9UEW8 / STK39_HUMAN
Protein Name	STE20/SPS1-related proline-alanine-rich protein kinase
Gene Name	Name: STK39 Synonyms:PASK;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9UEW8 DAG View
PRO Name	STE20/SPS1-related proline-alanine-rich protein kinase (human)
Definition	A STE20/SPS1-related proline-alanine-rich protein kinase that is encoded in the genome of human.
Short Label	hSTK39
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9UEW8 (STK39) as Substrate

Condensed View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
Y63	Phosphorylation		score1	PhosphoSitePlus
K83	Ubiquitination		score1	PhosphoSitePlus
K98	Ubiquitination		score1	PhosphoSitePlus
C116	Methylation		score1	IEDB	31844290
K160	Ubiquitination		score1	PhosphoSitePlus
Y182	Phosphorylation		score1	PhosphoSitePlus
T219	Phosphorylation		score1	PhosphoSitePlus
T224	Phosphorylation		score1	PhosphoSitePlus
K230	Ubiquitination		score1	PhosphoSitePlus
T231	Phosphorylation		score4	neXtProt PhosphoSitePlus Signor UniProt	16832045, 20463172, 34289367, ...21321328, 16083423, 17190791, 19633012, 16382158, 16263722, 16950202
T231	Phosphorylation	Q96J92 (WNK4)	score3	neXtProt	19633012, 20463172, 16083423
T231	Phosphorylation	Q9H4A3 (WNK1)	score4	neXtProt PhosphoSitePlus Signor	17190791, 16083423, 16263722
T231	Phosphorylation	Q9UEW8 (STK39)	score3	neXtProt	16382158, 16950202
T235	Phosphorylation		score4	neXtProt PhosphoSitePlus	16382158, 16950202
T235	Phosphorylation	Q9UEW8 (STK39)	score3	neXtProt	16382158, 16950202
Y273	Phosphorylation		score1	PhosphoSitePlus
Y276	Phosphorylation		score1	PhosphoSitePlus
Y306	Phosphorylation		score1	PhosphoSitePlus
S309	Phosphorylation		score3	neXtProt PhosphoSitePlus UniProt	14988727
S309	Phosphorylation	Q04759 (PRKCQ)	score3	neXtProt PhosphoSitePlus	14988727
K312	Acetylation		score1	PhosphoSitePlus
K312	Methylation		score1	PhosphoSitePlus
K312	Ubiquitination		score1	PhosphoSitePlus
K320	Methylation		score1	PhosphoSitePlus
K320	Ubiquitination		score1	PhosphoSitePlus
S323	Phosphorylation		score2	PhosphoSitePlus	14988727
S323	Phosphorylation	Q04759 (PRKCQ)	score2	PhosphoSitePlus	14988727
K324	Ubiquitination		score1	PhosphoSitePlus
K333	Ubiquitination		score1	PhosphoSitePlus
K341	Ubiquitination		score1	PhosphoSitePlus
K349	Acetylation		score2	PhosphoSitePlus UniProt	19608861
K349	Ubiquitination		score1	PhosphoSitePlus
T352	Phosphorylation		score1	PhosphoSitePlus
T354	Phosphorylation		score4	PhosphoSitePlus UniProt	23186163, 21733846
T354	Phosphorylation	Q9Y3S1 (WNK2)	score2	PhosphoSitePlus	21733846
S370	Phosphorylation		score2	PhosphoSitePlus UniProt	18088087
S371	Phosphorylation		score4	neXtProt PhosphoSitePlus Signor UniProt	20463172, 18088087, 16083423, ...16263722, 19633012, 17190791, 18270262, 21733846
S371	Phosphorylation	Q96J92 (WNK4)	score3	neXtProt	19633012, 20463172, 16083423
S371	Phosphorylation	Q9H4A3 (WNK1)	score4	neXtProt PhosphoSitePlus Signor	17190791, 18270262, 16083423, ...16263722
S371	Phosphorylation	Q9Y3S1 (WNK2)	score2	PhosphoSitePlus	21733846
S385	Phosphorylation		score2	PhosphoSitePlus UniProt	21406692, 18088087, 23186163, ...17487921, 19690332, 20068231
S401	Phosphorylation		score1	PhosphoSitePlus
K404	Ubiquitination		score1	PhosphoSitePlus
S430	Phosphorylation		score1	PhosphoSitePlus
Y444	Phosphorylation		score1	PhosphoSitePlus
S448	Phosphorylation		score1	PhosphoSitePlus
R469	Methylation		score1	PhosphoSitePlus
K512	Acetylation		score1	PhosphoSitePlus
K512	Ubiquitination		score1	PhosphoSitePlus
K515	Ubiquitination		score1	PhosphoSitePlus
K520	Ubiquitination		score1	PhosphoSitePlus

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S309	Phosphorylation		score1	HPRD	10980603
S309	Phosphorylation	Q04759 (PRKCQ)	score1	HPRD	10980603
S323	Phosphorylation		score1	HPRD	10980603
S323	Phosphorylation	Q04759 (PRKCQ)	score1	HPRD	10980603
S370	Phosphorylation		score0	HPRD	19651622, 18088087, 17081983
S371	Phosphorylation		score0	HPRD	19651622, 18088087
S385	Phosphorylation		score0	HPRD	19413330, 17322306, 18088087, ...18452278, 19651622, 18510355, 19415658, 20068231

Q9UEW8 (STK39) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
P55011 (SLC12A2)	T203	score4	neXtProt PhosphoSitePlus	16669787, 16950202, 16382158, ...21423148, 20091762
P55011 (SLC12A2)	T207	score4	neXtProt PhosphoSitePlus	16669787, 16950202, 16382158, ...21423148, 20091762
P55011 (SLC12A2)	T212	score4	neXtProt PhosphoSitePlus	16669787, 16950202, 16382158, ...21423148, 20091762
P55017 (SLC12A3)	T46	score4	neXtProt PhosphoSitePlus	18270262, 21423148, 20091762
P55017 (SLC12A3)	T55	score4	neXtProt PhosphoSitePlus	18270262, 21423148, 20091762
P55017 (SLC12A3)	T60	score4	neXtProt PhosphoSitePlus	18270262, 21423148, 20091762
P55017 (SLC12A3)	S91	score3	neXtProt	18270262, 21423148, 20091762
Q13621 (SLC12A1)	S91	score1	Signor	21321328
Q13621 (SLC12A1)	T95	score4	neXtProt PhosphoSitePlus Signor	21423148, 21321328, 20091762
Q13621 (SLC12A1)	T100	score4	neXtProt PhosphoSitePlus Signor	21423148, 21321328, 20091762
Q13621 (SLC12A1)	T105	score4	neXtProt PhosphoSitePlus Signor	21423148, 21321328, 20091762
Q9H2X9 (SLC12A5)	T6	score2	PhosphoSitePlus	24393035
Q9H2X9 (SLC12A5)	T1032	score2	PhosphoSitePlus	24393035
Q9UEW8 (STK39)	T231	score3	neXtProt	16382158, 16950202
Q9UEW8 (STK39)	T235	score3	neXtProt	16382158, 16950202
Q9UHW9 (SLC12A6)	S96	score3	PhosphoSitePlus	24043619, 24393035
Q9UHW9 (SLC12A6)	T160	score2	PhosphoSitePlus	24393035
Q9UHW9 (SLC12A6)	T1048	score2	PhosphoSitePlus	24393035
Q9UP95 (SLC12A4)	T5	score2	PhosphoSitePlus	24393035
Q9UP95 (SLC12A4)	T983	score2	PhosphoSitePlus	24393035
Q9Y666 (SLC12A7)	T973	score2	PhosphoSitePlus	24393035
Q9Y666 (SLC12A7)	T980	score2	PhosphoSitePlus	24393035
Q9Y6R1 (SLC4A4)	T49	score3	neXtProt	21317537, 23431199
Q9Y6R1 (SLC4A4)	S65	score4	neXtProt PhosphoSitePlus	21317537, 23431199

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
K160	N160	Biomuta	DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ icgc ]
Y182	C182	Biomuta	DOID:184 / bone cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T224	A224	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K312	T312	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
K341	E341	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S430	F430	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y444	H444	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y444	C444	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
R469	Q469	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R469	*	Biomuta	DOID:1319 / brain cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q9UEW8 (STK39)

Protein Information

Interactive Sequence View

Q9UEW8 (STK39) as Substrate

Q9UEW8 (STK39) as PTM Enzyme

PTM sites affected in variants