iPTMnet Report for Q9UDY2 (TJP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UDY2 / ZO2_HUMAN
Protein Name Tight junction protein ZO-2
Gene Name Name: TJP2
Synonyms:X104,ZO2;
Organism Homo sapiens (Human)

PRO ID PR:Q9UDY2
DAG View
PRO Name tight junction protein ZO-2 (human)
Definition A tight junction protein ZO-2 that is encoded in the genome of human.
Short Label hTJP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UDY2 (TJP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus   UniProt 23186163
T91 Phosphorylation PhosphoSitePlus
S130 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231
S150 Phosphorylation PhosphoSitePlus   UniProt 23186163
S153 Phosphorylation PhosphoSitePlus   UniProt 21406692
S156 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S168 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18088087
S170 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16083285, 18088087, 17081983, ...18669648, 23186163, 20068231
S174 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 23186163, ...17081983, 18669648, 18088087, 20068231
S186 Phosphorylation PhosphoSitePlus
S192 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S196 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus   UniProt 21406692
T212 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus   UniProt 21406692
S232 Phosphorylation PhosphoSitePlus   UniProt 23186163
S240 Phosphorylation PhosphoSitePlus
S244 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 18088087, ...17081983, 18669648, 23186163, 19690332, 20068231
Y249 Phosphorylation PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus
Y257 Phosphorylation PhosphoSitePlus
Y261 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
Y265 Phosphorylation PhosphoSitePlus
S266 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 16964243, 15302935, ...18669648, 23186163
Y269 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
S296 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
Y319 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus   UniProt 24275569
T333 Phosphorylation PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
T339 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
S394 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S398 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S400 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S406 Phosphorylation PhosphoSitePlus   UniProt 24275569
S413 Phosphorylation PhosphoSitePlus
S415 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 16083285, 23186163
Y423 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S424 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y426 Phosphorylation PhosphoSitePlus
Y428 Phosphorylation PhosphoSitePlus
S430 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...17081983
S431 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...24275569
S432 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S440 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S441 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T445 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S450 Phosphorylation PhosphoSitePlus
T455 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T457 Phosphorylation PhosphoSitePlus
K460 Methylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
T462 Phosphorylation PhosphoSitePlus
T468 Phosphorylation PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
Y479 Phosphorylation PhosphoSitePlus
T494 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y506 Phosphorylation PhosphoSitePlus
T510 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
Y574 Phosphorylation PhosphoSitePlus
T585 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
Y638 Phosphorylation PhosphoSitePlus
S702 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 24275569
T707 Phosphorylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
S713 Phosphorylation PhosphoSitePlus
K730 Methylation PhosphoSitePlus
K730 Sumoylation PhosphoSitePlus
K759 Ubiquitination PhosphoSitePlus
T760 Phosphorylation PhosphoSitePlus
S767 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K769 Ubiquitination PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus
T771 Phosphorylation PhosphoSitePlus
T778 Phosphorylation PhosphoSitePlus
T831 Phosphorylation PhosphoSitePlus
S832 Phosphorylation PhosphoSitePlus
S836 Phosphorylation PhosphoSitePlus
K838 Acetylation PhosphoSitePlus
S886 Phosphorylation PhosphoSitePlus
S902 Phosphorylation PhosphoSitePlus
Y903 Phosphorylation PhosphoSitePlus
T905 Phosphorylation PhosphoSitePlus
Y911 Phosphorylation PhosphoSitePlus
S913 Phosphorylation PhosphoSitePlus   UniProt 23186163
S916 Phosphorylation PhosphoSitePlus
S920 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T925 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
Y932 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T933 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S953 Phosphorylation PhosphoSitePlus
S961 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S966 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 23186163, 24275569
S978 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18088087, 18669648, ...24275569, 23186163
S979 Phosphorylation PhosphoSitePlus
S986 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18088087, 17081983, ...18669648, 24275569, 23186163, 20068231
K992 Ubiquitination PhosphoSitePlus
S1006 Phosphorylation PhosphoSitePlus
Y1007 Phosphorylation PhosphoSitePlus
S1012 Phosphorylation PhosphoSitePlus
Y1013 Phosphorylation PhosphoSitePlus
Y1015 Phosphorylation PhosphoSitePlus
K1016 Ubiquitination PhosphoSitePlus
T1027 Phosphorylation PhosphoSitePlus
S1031 O-Glycosylation GlyGen 31373491
S1031 Phosphorylation PhosphoSitePlus
T1032 O-Glycosylation GlyGen 28510447, 31373491
Y1035 Phosphorylation PhosphoSitePlus
S1048 Phosphorylation PhosphoSitePlus
S1053 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1054 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1067 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
S1068 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
Y1118 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 23186163, 16497976
T1124 Phosphorylation PhosphoSitePlus
T1131 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17287340
T1135 Phosphorylation PhosphoSitePlus
S1137 Phosphorylation PhosphoSitePlus
S1147 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y1150 Phosphorylation PhosphoSitePlus
S1156 Phosphorylation PhosphoSitePlus
Y1157 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1159 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18088087, 17081983, ...15302935, 18669648, 24275569, 23186163, 19690332, 20068231
Y1166 Phosphorylation PhosphoSitePlus
S1171 Phosphorylation PhosphoSitePlus
S1174 Phosphorylation PhosphoSitePlus
R1176 Methylation PhosphoSitePlus
Y1178 Phosphorylation PhosphoSitePlus
Y1179 Phosphorylation PhosphoSitePlus
S1182 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y32 Phosphorylation HPRD 20068231
T35 Phosphorylation HPRD 20068231
S130 Phosphorylation HPRD 17322306, 20058876, 18767875, ...19664994, 19664995, 19651622, 18669648, 19415658, 20068231
S163 Phosphorylation HPRD 20068231
S168 Phosphorylation HPRD 19651622, 18088087, 17081983
S170 Phosphorylation HPRD 18088087, 17081983, 19651622, ...18669648, 20166139, 20068231
S174 Phosphorylation HPRD 17322306, 18088087, 18767875, ...19664994, 19651622, 18669648, 20166139, 19415658, 20068231
S192 Phosphorylation HPRD 17081983, 20068231
S196 Phosphorylation HPRD 20068231
S244 Phosphorylation HPRD 18088087, 17081983, 19664994, ...19664995, 19651622, 18669648, 20166139, 20068231, 18212344
Y261 Phosphorylation HPRD 15570572
S266 Phosphorylation HPRD 18088087, 16964243, 17322306, ...18669648, 20166139, 20068231
S296 Phosphorylation HPRD 15302935
S394 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S398 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S400 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S406 Phosphorylation HPRD 17081983
S410 Phosphorylation HPRD 17081983
S413 Phosphorylation HPRD 17081983
S415 Phosphorylation HPRD 18088087, 20068231
Y423 Phosphorylation HPRD 18669648, 17081983
S424 Phosphorylation HPRD 17081983
Y428 Phosphorylation HPRD 17081983, 20068231
S430 Phosphorylation HPRD 19651622, 18669648, 20068231
S431 Phosphorylation HPRD 19651622, 18669648, 20068231
S432 Phosphorylation HPRD 19651622, 18669648, 17081983
S440 Phosphorylation HPRD 17081983
S441 Phosphorylation HPRD 17081983, 20068231
T445 Phosphorylation HPRD 17081983
T455 Phosphorylation HPRD 18669648, 19664995, 20068231
T494 Phosphorylation HPRD 20068231
Y506 Phosphorylation HPRD 20068231
T510 Phosphorylation HPRD 20068231
S702 Phosphorylation HPRD 18088087
S770 Phosphorylation HPRD 17081983
T771 Phosphorylation HPRD 17081983
S913 Phosphorylation HPRD 20068231
S920 Phosphorylation HPRD 18669648, 20068231
T925 Phosphorylation HPRD 18669648, 20068231
Y932 Phosphorylation HPRD 18669648
T933 Phosphorylation HPRD 18669648, 20068231
S961 Phosphorylation HPRD 18669648
S966 Phosphorylation HPRD 18088087, 17081983, 18212344
S978 Phosphorylation HPRD 18088087, 17081983, 20230923, ...18669648, 20166139, 20068231, 18212344
S979 Phosphorylation HPRD 17081983, 20230923
S986 Phosphorylation HPRD 18088087, 17081983, 20230923, ...19664994, 19664995, 19651622, 18669648, 20068231, 18212344
T1027 Phosphorylation HPRD 19413330, 19664994, 19664995
S1053 Phosphorylation HPRD 18669648
T1054 Phosphorylation HPRD 18669648
S1067 Phosphorylation HPRD 19413330, 18669648, 20068231, ...18452278
S1068 Phosphorylation HPRD 19413330, 18669648
Y1118 Phosphorylation HPRD 19901323, 15144186, 16497976
T1131 Phosphorylation HPRD 18669648, 17287340
S1147 Phosphorylation HPRD 20068231
Y1150 Phosphorylation HPRD 20068231
S1156 Phosphorylation HPRD 17081983, 20068231
Y1157 Phosphorylation HPRD 18669648, 17081983
S1159 Phosphorylation HPRD 19413330, 18088087, 18212344, ...15302935, 19664994, 19651622, 18669648, 20166139, 19415658, 20068231
S1171 Phosphorylation HPRD 17081983
S1174 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
Y261 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
Y426 Phosphorylation PhosphoSitePlus
Y428 Phosphorylation PhosphoSitePlus
Y506 Phosphorylation PhosphoSitePlus
Y971 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q14847 (LASP1) S146 Q9UDY2 (TJP2) unknown eFIP 22665060
Phosphorylation Q16625 (OCLN) T404 Q9UDY2 (TJP2) decreased_association eFIP 23758859


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y32 H32 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S130 R130 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S170 N170 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S174 N174 Biomuta DOID:4159 / skin cancer [ cosmic ]
S232 T232 Biomuta DOID:1324 / lung cancer [ cosmic ]
S244 R244 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S292 L292 Biomuta DOID:4159 / skin cancer [ cosmic ]
S325 R325 Biomuta DOID:4159 / skin cancer [ cosmic ]
T335 M335 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S406 T406 Biomuta DOID:4159 / skin cancer [ cosmic ]
S430 C430 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T445 M445 Biomuta DOID:363 / uterine cancer [ cosmic ]
K460 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S499 G499 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S499 I499 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y574 C574 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S606 L606 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S713 I713 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K759 N759 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T760 M760 Biomuta DOID:263 / kidney cancer [ cosmic ]
S770 T770 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T831 A831 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S836 Y836 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K838 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S886 C886 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S966 N966 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y971 C971 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S1031 Y1031 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T1054 A1054 Biomuta DOID:4362 / cervical cancer [ icgc ]
S1067 I1067 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y1118 C1118 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
T1124 M1124 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T1131 M1131 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1135 M1135 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y1166 C1166 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1176 H1176 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
R1176 C1176 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:363 / uterine cancer [ cosmic, icgc ]
S1182 F1182 Biomuta DOID:5041 / esophageal cancer [ cosmic ]