iPTMnet Report for Q9UD71 (PPP1R1B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UD71 / PPR1B_HUMAN
Protein Name Protein phosphatase 1 regulatory subunit 1B
Gene Name Name: PPP1R1B
Synonyms:DARPP32;
Organism Homo sapiens (Human)

PRO ID PR:Q9UD71
DAG View
PRO Name protein phosphatase 1 regulatory subunit 1B (human)
Definition A protein phosphatase 1 regulatory subunit 1B that is encoded in the genome of human.
Short Label hPPP1R1B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UD71 (PPP1R1B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
R29 Methylation PhosphoSitePlus
T34 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 33553717, 16965177, 12065642, ...8386374, 18954090, 20838877, 17194217, 21904525, 2173704, 12538871, 27998980, 20236543, 31447328, 21564097, 26872373, 20808799, 15726118, 25692798, 17027969, 11717349, 18044203, 27584878, 17686497, 21811441, 26178297, 15359085, 29782621, 22179181
T34 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 15726118
S45 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
K65 Methylation PhosphoSitePlus
Y74 Phosphorylation PhosphoSitePlus
T75 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 33553717, 17194217, 26178297, ...11013232, 17027969, 10604473, 30043390, 11050161, 32519838, 12065642, 22820052, 20838877, 16965177, 20236543, 26872373, 18808062
T75 Phosphorylation Q00535 (CDK5) RLIMS-P+ 11013232, 22820052
S78 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P 17194217, 20236543
Y116 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P 21564097, 17194217, 20236543
S148 Phosphorylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T34 Phosphorylation HPRD 10604473
T34 Phosphorylation P17612 (PRKACA) HPRD 10604473
S45 Phosphorylation HPRD 2557337
S45 Phosphorylation P19784 (CSNK2A2) HPRD 2557337
S45 Phosphorylation P68400 (CSNK2A1) HPRD 2557337
T75 Phosphorylation HPRD 10604473
T75 Phosphorylation Q00535 (CDK5) HPRD 10604473
S102 Phosphorylation HPRD 2557337
S102 Phosphorylation P19784 (CSNK2A2) HPRD 2557337
S102 Phosphorylation P68400 (CSNK2A1) HPRD 2557337
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD 2557337
S9 Phosphorylation P19784 (CSNK2A2) HPRD 2557337
S9 Phosphorylation P68400 (CSNK2A1) HPRD 2557337
T39 Phosphorylation HPRD 10604473
T39 Phosphorylation Q00535 (CDK5) HPRD 10604473
S66 Phosphorylation HPRD 2557337
S66 Phosphorylation P19784 (CSNK2A2) HPRD 2557337
S66 Phosphorylation P68400 (CSNK2A1) HPRD 2557337


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048869 (hPPP1R1B/Phos:1) pS102 PRO
PR:000048870 (hPPP1R1B/Phos:2) pS102,pS137 PRO
PR:000048871 (hPPP1R1B/Phos:3) pS137 PRO
PR:000048872 (hPPP1R1B/Phos:4) pT34 PRO
PR:000048873 (hPPP1R1B/Phos:5) pT34,pS102 PRO
PR:000048874 (hPPP1R1B/Phos:6) pT34,pS102,pS137 PRO
PR:000048875 (hPPP1R1B/Phos:7) pT34,pS137 PRO
PR:000048876 (hPPP1R1B/Phos:8) pT34,pT75 PRO
PR:000048877 (hPPP1R1B/Phos:9) pT34,pT75,pS102 PRO
PR:000048878 (hPPP1R1B/Phos:10) pT34,pT75,pS102,pS137 PRO
PR:000048879 (hPPP1R1B/Phos:11) pT34,pT75,pS137 PRO
PR:000048880 (hPPP1R1B/Phos:12) pT75 PRO
PR:000048881 (hPPP1R1B/Phos:13) pT75,pS102 PRO
PR:000048882 (hPPP1R1B/Phos:14) pT75,pS102,pS137 PRO
PR:000048883 (hPPP1R1B/Phos:15) pT75,pS137 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R29 L29 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S52 C52 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K65 R65 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S188 I188 Biomuta DOID:263 / kidney cancer [ cosmic ]