iPTMnet Report for Q9UBZ4 (APEX2)
Protein Information
| UniProt AC / UniProt ID | Q9UBZ4 / APEX2_HUMAN |
| Protein Name | DNA-(apurinic or apyrimidinic site) endonuclease 2 |
| Gene Name | Name: APEX2 Synonyms:APE2,APEXL2,XTH2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9UBZ4 |
| PRO Name | DNA-(apurinic or apyrimidinic site) endonuclease 2 (human) |
| Definition | A DNA-(apurinic or apyrimidinic site) endonuclease 2 that is encoded in the genome of human. |
| Short Label | hAPEX2 |
| Category | organism-gene |
DAG ViewQ9UBZ4 (APEX2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K139 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K146 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T149 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y175 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K253 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C305 | Methylation | score1 | IEDB | 31844290 | ||
| K338 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S349 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus | 18669648 | ||
| K371 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S407 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K449 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K457 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S518 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K139 | R139 | Biomuta | DOID:363 / uterine cancer [ icgc ] |
