iPTMnet Report for Q9UBY0 (SLC9A2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBY0 / SL9A2_HUMAN
Protein Name Sodium/hydrogen exchanger 2
Gene Name Name: SLC9A2
Synonyms:NHE2;
Organism Homo sapiens (Human)

PRO ID PR:Q9UBY0
DAG View
PRO Name sodium/hydrogen exchanger 2 (human)
Definition A sodium/hydrogen exchanger 2 that is encoded in the genome of human.
Short Label hSLC9A2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBY0 (SLC9A2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S54 O-Glycosylation GlyGen 30459171
Y356 Phosphorylation PhosphoSitePlus
Y361 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
Y503 Phosphorylation PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
Y610 Phosphorylation PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus
S647 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus
S661 Phosphorylation PhosphoSitePlus
T662 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
Y667 Phosphorylation PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus
T674 Phosphorylation PhosphoSitePlus
K679 Acetylation PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
S745 Phosphorylation PhosphoSitePlus
T746 Phosphorylation PhosphoSitePlus
T749 Phosphorylation PhosphoSitePlus
S752 Phosphorylation PhosphoSitePlus
T757 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S54 R54 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y356 D356 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K536 N536 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S623 C623 Biomuta DOID:1324 / lung cancer [ cosmic ]
S661 F661 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ]
S665 F665 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S669 F669 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T674 M674 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T746 S746 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T749 K749 Biomuta DOID:1324 / lung cancer [ cosmic ]
T757 P757 Biomuta DOID:1612 / breast cancer [ cosmic ]
T757 N757 Biomuta DOID:1324 / lung cancer [ cosmic ]