Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBU9 / NXF1_HUMAN
Protein Name Nuclear RNA export factor 1
Gene Name Name: NXF1
Synonyms:TAP;
Organism Homo sapiens (Human)

PRO ID PR:Q9UBU9
DAG View
PRO Name nuclear RNA export factor 1 (human)
Definition A nuclear RNA export factor 1 that is encoded in the genome of human.
Short Label hNXF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBU9 (NXF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
K6 Ubiquitination PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y33 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
Y75 Phosphorylation PhosphoSitePlus
T76 Phosphorylation PhosphoSitePlus
T77 Phosphorylation PhosphoSitePlus
R82 Methylation PhosphoSitePlus
T85 Phosphorylation PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
R105 Methylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
C143 S-Nitrosylation dbSNO 24105792
T148 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
K230 Methylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
K304 Sumoylation PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
T554 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
T562 Phosphorylation PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S556 Phosphorylation HPRD 18691976
S557 Phosphorylation HPRD 20068231
S558 Phosphorylation HPRD 20068231, 18452278


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O94901 (SUN1) S113 Q9UBU9 (NXF1) decreased_association eFIP 28831067


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 E2 Biomuta DOID:3571 / liver cancer [ icgc ]
K6 E6 Biomuta DOID:4159 / skin cancer [ icgc ]
T76 A76 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
R82 Q82 Biomuta DOID:1612 / breast cancer [ tcga ]
T148 A148 Biomuta DOID:363 / uterine cancer [ tcga ]
S223 P223 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S223 C223 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S299 C299 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S558 R558 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]