Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBT6 / POLK_HUMAN
Protein Name DNA polymerase kappa
Gene Name Name: POLK
Synonyms:DINB1;
Organism Homo sapiens (Human)

PRO ID PR:Q9UBT6
DAG View
PRO Name DNA polymerase kappa (human)
Definition A DNA polymerase kappa that is encoded in the genome of human.
Short Label hPOLK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBT6 (POLK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K12 Ubiquitination PhosphoSitePlus
K25 Acetylation PhosphoSitePlus
K25 Sumoylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
T44 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K55 Sumoylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K224 Sumoylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
K557 Sumoylation PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
K576 Ubiquitination PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
K584 Sumoylation PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
K603 Ubiquitination PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
Y686 Phosphorylation PhosphoSitePlus
K691 Acetylation PhosphoSitePlus
K691 Ubiquitination PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
S715 Phosphorylation PhosphoSitePlus
K722 Ubiquitination PhosphoSitePlus
K725 Ubiquitination PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
K772 Ubiquitination PhosphoSitePlus
K814 Sumoylation PhosphoSitePlus
K814 Ubiquitination PhosphoSitePlus
K822 Ubiquitination PhosphoSitePlus
S824 Phosphorylation PhosphoSitePlus
S825 Phosphorylation PhosphoSitePlus
T828 Phosphorylation PhosphoSitePlus
S830 Phosphorylation PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus
K836 Ubiquitination PhosphoSitePlus
T839 Phosphorylation PhosphoSitePlus
T848 Phosphorylation PhosphoSitePlus
K849 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T372 Phosphorylation HPRD 17322306
S827 Phosphorylation HPRD 17322306


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K12 I12 Biomuta DOID:2394 / ovarian cancer [ tcga ]
K55 R55 Biomuta DOID:3571 / liver cancer [ tcga ]
K158 N158 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K353 T353 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S528 I528 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K564 N564 Biomuta DOID:10283 / prostate cancer [ clinvar ]
K590 R590 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y686 S686 Biomuta DOID:1909 / melanoma [ tcga ]
S824 I824 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S830 R830 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K836 T836 Biomuta DOID:363 / uterine cancer [ tcga ]
T848 K848 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]