iPTMnet Report for Q9UBP6 (METTL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBP6 / TRMB_HUMAN
Protein Name tRNA (guanine-N(7)-)-methyltransferase
Gene Name Name: METTL1
Synonyms:C12orf1;
Organism Homo sapiens (Human)

PRO ID PR:Q9UBP6
DAG View
PRO Name tRNA (guanine-N(7)-)-methyltransferase (human)
Definition A tRNA (guanine-N(7)-)-methyltransferase that is encoded in the genome of human.
Short Label hMETTL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBP6 (METTL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
K18 Ubiquitination PhosphoSitePlus
R24 Methylation PhosphoSitePlus
S27 Phosphorylation Q15418 (RPS6KA1) , P31749 (AKT1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 24275569, 25233213, ...15861136, 36599985, 3627513
K111 Ubiquitination PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K250 Acetylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
T268 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
T271 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation Q15418 (RPS6KA1) , P31749 (AKT1) HPRD 15861136
Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation P31749 (AKT1) , Q15418 (RPS6KA1) HPRD 15861136
S128 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S128 R128 Biomuta DOID:1324 / lung cancer [ cosmic ]