Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9UBM7 / DHCR7_HUMAN
Protein Name 7-dehydrocholesterol reductase
Gene Name Name: DHCR7
Organism Homo sapiens (Human)

DAG View
PRO Name 7-dehydrocholesterol reductase (human)
Definition A 7-dehydrocholesterol reductase that is encoded in the genome of human.
Short Label hDHCR7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9UBM7 (DHCR7) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K4 Ubiquitination PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
S14 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...19369195, 19007248, 19691289, 19651622, 24275569, 20166139, 19690332, 20068231
T19 Phosphorylation HPRD   PhosphoSitePlus 20068231
S25 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
C380 S-Nitrosylation dbSNO 26338901
Y382 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
K454 Acetylation PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
Y468 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K88 R88 Biomuta DOID:3571 / liver cancer [ icgc ]
T135 I135 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]