iPTMnet Report for Q9UBM7 (DHCR7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBM7 / DHCR7_HUMAN
Protein Name 7-dehydrocholesterol reductase
Gene Name Name: DHCR7
Synonyms:D7SR;
Organism Homo sapiens (Human)

PRO ID PR:Q9UBM7
DAG View
PRO Name 7-dehydrocholesterol reductase (human)
Definition A 7-dehydrocholesterol reductase that is encoded in the genome of human.
Short Label hDHCR7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBM7 (DHCR7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Acetylation IEDB 34357683
K4 Ubiquitination PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
S14 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...19369195, 19007248, 19691289, 19651622, 24275569, 20166139, 19690332, 20068231
T19 Phosphorylation HPRD   PhosphoSitePlus 20068231
S25 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
C118 Methylation IEDB 31844290
T135 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
C298 Methylation IEDB 31844290
K358 Ubiquitination PhosphoSitePlus
C368 Methylation IEDB 31844290
K376 Ubiquitination PhosphoSitePlus
C380 S-Nitrosylation dbSNO 26338901
Y382 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
K454 Acetylation PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
Y468 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 L5 Biomuta DOID:4159 / skin cancer [ cosmic ]
S25 C25 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K88 R88 Biomuta DOID:4159 / skin cancer [ cosmic ]
K88 N88 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T135 I135 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S397 L397 Biomuta DOID:4159 / skin cancer [ cosmic ]
K454 N454 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]