iPTMnet Report for Q9UBL3 (ASH2L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBL3 / ASH2L_HUMAN
Protein Name Set1/Ash2 histone methyltransferase complex subunit ASH2
Gene Name Name: ASH2L
Synonyms:ASH2L1;
Organism Homo sapiens (Human)

PRO ID PR:Q9UBL3
DAG View
PRO Name Set1/Ash2 histone methyltransferase complex subunit ASH2 (human)
Definition A Set1/Ash2 histone methyltransferase complex subunit ASH2 that is encoded in the genome of human.
Short Label hASH2L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBL3 (ASH2L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
T84 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus   UniProt 20068231
K193 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
K294 Acetylation PhosphoSitePlus
R296 Methylation UniProt 21285357
K301 Methylation PhosphoSitePlus
K312 Methylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus   UniProt 23186163
S321 Phosphorylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
R388 Methylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
R398 Methylation PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus
Y517 Phosphorylation PhosphoSitePlus
Y519 Phosphorylation PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S101 Phosphorylation HPRD 19651622, 20068231, 18452278
S316 Phosphorylation HPRD 20068231
S623 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K253 E253 Biomuta DOID:4159 / skin cancer [ cosmic ]
K312 N312 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S316 I316 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K338 Q338 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R388 Q388 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R388 * Biomuta DOID:4159 / skin cancer [ cosmic ]
R398 W398 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K405 N405 Biomuta DOID:1319 / brain cancer [ cosmic ]
S459 Y459 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K531 N531 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K534 T534 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K534 N534 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]